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Evasion of host antiviral innate immunity by HSV-1, an update

Overview of attention for article published in Virology Journal, March 2016
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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167 Mendeley
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Title
Evasion of host antiviral innate immunity by HSV-1, an update
Published in
Virology Journal, March 2016
DOI 10.1186/s12985-016-0495-5
Pubmed ID
Authors

Chenhe Su, Guoqing Zhan, Chunfu Zheng

Abstract

Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide range of antiviral proteins to control infection of incoming pathogens. In some cases, viral invasion also induces DNA damage response, autophagy, endoplasmic reticulum stress, cytoplasmic stress granules and other innate immune responses, which in turn affect viral infection. However, HSV-1 has evolved multiple strategies to evade host innate responses and facilitate its infection. In this review, we summarize the most recent findings on the molecular mechanisms utilized by HSV-1 to counteract host antiviral innate immune responses with specific focus on the type I IFN signal pathway.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 167 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 19%
Student > Bachelor 30 18%
Student > Master 21 13%
Researcher 15 9%
Student > Doctoral Student 13 8%
Other 25 15%
Unknown 31 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 41 25%
Immunology and Microbiology 33 20%
Agricultural and Biological Sciences 30 18%
Medicine and Dentistry 10 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Other 14 8%
Unknown 35 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2023.
All research outputs
#15,242,689
of 25,483,400 outputs
Outputs from Virology Journal
#1,557
of 3,395 outputs
Outputs of similar age
#156,869
of 314,076 outputs
Outputs of similar age from Virology Journal
#26
of 54 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,395 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,076 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.