Title |
Evasion of host antiviral innate immunity by HSV-1, an update
|
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Published in |
Virology Journal, March 2016
|
DOI | 10.1186/s12985-016-0495-5 |
Pubmed ID | |
Authors |
Chenhe Su, Guoqing Zhan, Chunfu Zheng |
Abstract |
Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide range of antiviral proteins to control infection of incoming pathogens. In some cases, viral invasion also induces DNA damage response, autophagy, endoplasmic reticulum stress, cytoplasmic stress granules and other innate immune responses, which in turn affect viral infection. However, HSV-1 has evolved multiple strategies to evade host innate responses and facilitate its infection. In this review, we summarize the most recent findings on the molecular mechanisms utilized by HSV-1 to counteract host antiviral innate immune responses with specific focus on the type I IFN signal pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 167 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 19% |
Student > Bachelor | 30 | 18% |
Student > Master | 21 | 13% |
Researcher | 15 | 9% |
Student > Doctoral Student | 13 | 8% |
Other | 25 | 15% |
Unknown | 31 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 41 | 25% |
Immunology and Microbiology | 33 | 20% |
Agricultural and Biological Sciences | 30 | 18% |
Medicine and Dentistry | 10 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 14 | 8% |
Unknown | 35 | 21% |