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Attention Score in Context
| Title |
Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner
|
|---|---|
| Published in |
Journal of Neuroinflammation, March 2015
|
| DOI | 10.1186/s12974-015-0270-3 |
| Pubmed ID | |
| Authors |
Jie Pan, Jia-li Jin, Hui-ming Ge, Kai-lin Yin, Xiang Chen, Li-juan Han, Yan Chen, Lai Qian, Xiao-xi Li, Yun Xu |
| Abstract |
Activation of microglia plays a crucial role in immune and inflammatory processes after ischemic stroke. Microglia is reported with two opposing activated phenotypes, namely, classic phenotype (M1) and the alternative phenotype (M2). Inhibiting M1 while stimulating M2 has been suggested as a potential therapeutic approach in the treatment of stroke. In this study, we indicated that a novel natural anti-oxidant extracted from the Chinese plant Hopea hainanensis, malibatol A (MA), decreased the infarct size and alleviated the brain injury after mice middle cerebral artery occlusion (MCAO). MA inhibited expression inflammatory cytokines in not only MCAO mice but also lipopolysaccharide (LPS)-stimulated microglia. Moreover, treatment of MA decreased M1 markers (CD16, CD32, and CD86) and increased M2 markers (CD206, YM-1) while promoting the activation of nuclear receptor PPARγ. MA has anti-inflammatory effects in MCAO mice in a PPARγ-dependent manner, making it a potential candidate for stroke treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 100 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 22% |
| Student > Ph. D. Student | 19 | 19% |
| Student > Master | 13 | 13% |
| Researcher | 11 | 11% |
| Student > Doctoral Student | 7 | 7% |
| Other | 11 | 11% |
| Unknown | 19 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 19% |
| Agricultural and Biological Sciences | 19 | 19% |
| Neuroscience | 18 | 18% |
| Biochemistry, Genetics and Molecular Biology | 13 | 13% |
| Immunology and Microbiology | 3 | 3% |
| Other | 13 | 13% |
| Unknown | 17 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2022.
All research outputs
#2,952,134
of 22,880,230 outputs
Outputs from Journal of Neuroinflammation
#514
of 2,644 outputs
Outputs of similar age
#39,586
of 261,692 outputs
Outputs of similar age from Journal of Neuroinflammation
#5
of 46 outputs
Altmetric has tracked 22,880,230 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,644 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.