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Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

Overview of attention for article published in Journal of Neuroinflammation, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

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135 Dimensions

Readers on

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90 Mendeley
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Title
Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner
Published in
Journal of Neuroinflammation, March 2015
DOI 10.1186/s12974-015-0270-3
Pubmed ID
Authors

Jie Pan, Jia-li Jin, Hui-ming Ge, Kai-lin Yin, Xiang Chen, Li-juan Han, Yan Chen, Lai Qian, Xiao-xi Li, Yun Xu

Abstract

Activation of microglia plays a crucial role in immune and inflammatory processes after ischemic stroke. Microglia is reported with two opposing activated phenotypes, namely, classic phenotype (M1) and the alternative phenotype (M2). Inhibiting M1 while stimulating M2 has been suggested as a potential therapeutic approach in the treatment of stroke. In this study, we indicated that a novel natural anti-oxidant extracted from the Chinese plant Hopea hainanensis, malibatol A (MA), decreased the infarct size and alleviated the brain injury after mice middle cerebral artery occlusion (MCAO). MA inhibited expression inflammatory cytokines in not only MCAO mice but also lipopolysaccharide (LPS)-stimulated microglia. Moreover, treatment of MA decreased M1 markers (CD16, CD32, and CD86) and increased M2 markers (CD206, YM-1) while promoting the activation of nuclear receptor PPARγ. MA has anti-inflammatory effects in MCAO mice in a PPARγ-dependent manner, making it a potential candidate for stroke treatment.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Spain 1 1%
Unknown 88 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 21%
Student > Bachelor 18 20%
Student > Master 13 14%
Researcher 11 12%
Student > Doctoral Student 6 7%
Other 9 10%
Unknown 14 16%
Readers by discipline Count As %
Neuroscience 19 21%
Medicine and Dentistry 18 20%
Agricultural and Biological Sciences 17 19%
Biochemistry, Genetics and Molecular Biology 11 12%
Chemistry 3 3%
Other 9 10%
Unknown 13 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2022.
All research outputs
#2,780,703
of 21,821,479 outputs
Outputs from Journal of Neuroinflammation
#485
of 2,519 outputs
Outputs of similar age
#45,557
of 280,590 outputs
Outputs of similar age from Journal of Neuroinflammation
#2
of 14 outputs
Altmetric has tracked 21,821,479 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,519 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.