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Prevalence, risk factors and molecular epidemiology of highly resistant gram negative rods in hospitalized patients in the Dutch region Kennemerland

Overview of attention for article published in Antimicrobial Resistance and Infection Control, March 2016
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8 tweeters

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Title
Prevalence, risk factors and molecular epidemiology of highly resistant gram negative rods in hospitalized patients in the Dutch region Kennemerland
Published in
Antimicrobial Resistance and Infection Control, March 2016
DOI 10.1186/s13756-016-0107-6
Pubmed ID
Authors

Dennis Souverein, Sjoerd M. Euser, Bjorn L. Herpers, Bram Diederen, Patricia Houtman, Marina van Seventer, Ingeborg van Ess, Jan Kluytmans, John W. A. Rossen, Jeroen W. Den Boer, Souverein, Dennis, Euser, Sjoerd M, Herpers, Bjorn L, Diederen, Bram, Houtman, Patricia, van Seventer, Marina, van Ess, Ingeborg, Kluytmans, Jan, Rossen, John W A, Den Boer, Jeroen W

Abstract

This paper describes (1) the Highly Resistant Gram Negative Rod (HR-GNR) prevalence rate, (2) their genotypes, acquired resistance genes and (3) associated risk factors of HR-GNR colonization among the hospitalized population in the Dutch region Kennemerland. Between 1 October 2013 and 31 March 2014, cross-sectional prevalence measurements were performed in three regional hospitals as part of each hospitals infection control program. Rectal swabs were analyzed at the Regional Public Health Laboratory Kennemerland by direct culturing. Genotypes and acquired resistance genes of positive isolates were determined using Whole Genome Sequencing with the MiSeq instrument (Illumina). Association between several independent variables and HR-GNR positivity was examined using logistic regression models. Out of 427 patients, 24 HR-GNR positive isolates were recovered from 22 patients, resulting in a regional HR-GNR colonization prevalence (95 % CI) of 5.2 % (3.6-7.9). Of these 22 positive patients, 15 were Extended Spectrum Beta-Lactamase (ESBL) positive (3.5 % (2.1-5.7)), 7 patients were positive for a Fluoroquinolones and Aminoglycosides (Q&A) resistant Enterobacteriaceae (1.6 % (0.8-3.3)) and from one patient (0.2 % (0-1.3)) a Stenotrophomonas maltophilia resistant towards co-trimoxazole was isolated. No carbapenemase producing Enterobacteriaceae (CPE), multi-resistant Acinetobacter species or multi-resistant Pseudomonas aeruginosa were isolated. The ESBL genes found were bla CTX-M-1 (n = 4, 25.0 %), bla CTX-M-15 (n = 3, 18.8 %), bla CTX-M-27 (n = 2, 12.5 %), bla CTX-M-14b (n = 2, 12.5 %), bla CTX-M-9 (n = 2, 12.5 %), bla CTX-M-14 (n = 1, 6.3 %), bla CTX-M-3 (n = 1, 6.3 %), bla SHV-11 (n = 1, 6.3 %) and bla SHV-12 (n = 1, 6.3 %). Being known HR-GNR positive in the past was the only significant associated risk factor for HR-GNR positivity, odds ratio (95 % CI): 7.32 (1.82-29.35), p-value = 0.005. Similar ESBL prevalence rates and genotypes (3.5 %) were found in comparison to other Dutch studies. When previously HR-GNR positive patients are readmitted, they should be screened for HR-GNR colonization since colonization with GR-GNRs could be prolonged. We recommend for future studies to include all defined HR-GNRs in addition to ESBLs in prevalence studies, in order to obtain a more comprehensive overview of colonization with HR-GNRs.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 26%
Student > Ph. D. Student 7 17%
Researcher 5 12%
Student > Bachelor 4 10%
Student > Postgraduate 3 7%
Other 10 24%
Unknown 2 5%
Readers by discipline Count As %
Medicine and Dentistry 18 43%
Immunology and Microbiology 9 21%
Biochemistry, Genetics and Molecular Biology 5 12%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 1 2%
Other 2 5%
Unknown 4 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2016.
All research outputs
#4,521,960
of 17,934,718 outputs
Outputs from Antimicrobial Resistance and Infection Control
#470
of 1,038 outputs
Outputs of similar age
#70,465
of 272,949 outputs
Outputs of similar age from Antimicrobial Resistance and Infection Control
#1
of 5 outputs
Altmetric has tracked 17,934,718 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,038 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,949 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them