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Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

Overview of attention for article published in Arthritis Research & Therapy, February 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

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6 X users
patent
1 patent

Citations

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22 Dimensions

Readers on

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25 Mendeley
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Title
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway
Published in
Arthritis Research & Therapy, February 2012
DOI 10.1186/ar3750
Pubmed ID
Authors

Sang-il Lee, David L Boyle, Andres Berdeja, Gary S Firestein

Abstract

The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthritis. Cytokine-induced JNK activation is strictly dependent on the mitogen-activated protein kinase kinase 7 (MKK7) in fibroblast-like synoviocytes (FLS). Therefore, we evaluated whether targeting MKK7 using anti-sense oligonucleotides (ASO) would decrease JNK activation and severity in K/BxN serum transfer arthritis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
India 1 4%
Denmark 1 4%
Unknown 22 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 20%
Student > Doctoral Student 4 16%
Student > Bachelor 3 12%
Other 3 12%
Student > Master 3 12%
Other 4 16%
Unknown 3 12%
Readers by discipline Count As %
Medicine and Dentistry 9 36%
Agricultural and Biological Sciences 7 28%
Biochemistry, Genetics and Molecular Biology 3 12%
Psychology 1 4%
Nursing and Health Professions 1 4%
Other 2 8%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2015.
All research outputs
#4,369,297
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#985
of 3,381 outputs
Outputs of similar age
#27,097
of 168,982 outputs
Outputs of similar age from Arthritis Research & Therapy
#6
of 61 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,982 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.