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Performance characteristics between TDx®FLx and TBA™-25FR for the therapeutic drug monitoring of methotrexate

Overview of attention for article published in Journal of Pharmaceutical Health Care and Sciences, March 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

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3 tweeters
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1 Facebook page

Citations

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3 Dimensions

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8 Mendeley
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Title
Performance characteristics between TDx®FLx and TBA™-25FR for the therapeutic drug monitoring of methotrexate
Published in
Journal of Pharmaceutical Health Care and Sciences, March 2016
DOI 10.1186/s40780-016-0042-y
Pubmed ID
Authors

Tetsuya Kaneko, Takashi Fujioka, Yosuke Suzuki, Yuhki Sato, Hiroki Itoh

Abstract

High-dose methotrexate (HDMTX) is used in the treatment of certain malignancies, including leptomeningeal metastases, systemic non-Hodgkin lymphoma, acute lymphoblastic leukemia, and osteosarcoma. High circulating levels of methotrexate can cause severe myelosuppression. The present study aimed to examine the differences in plasma MTX concentrations measured by two immunoassay systems currently available in the Japanese market, a TDX/FLX analyzer and a TBA-25FR analyzer. A total of 69 plasma samples from 16 patients were assayed by a fluorescence polarization immunoassay technique using a TDx/FLx analyzer (Abbott Diagnostics, Chicago, Illinois, U.S.A.) and a homogeneous enzyme immunoassay technique using a TBA-25FR analyzer (Toshiba Medical Systems, Tokyo, Japan). Assay results were very consistent between the two systems, with good correlation 24 h after the start of treatment (TBA-25FR = 1.06・TDX/FLX, -1.31, r = 0.99), 48 h after the start of treatment (TBA-25FR = 1.00・TDX/FLX, +0.027, r > 0.99), and 72 h after the start of treatment (TBA-25FR = 1.09・TDX/FLX, +0.011, r > 0.99). The calibration curve spanned one order of magnitude with a linear working range from the lowest to the highest standard. The standard deviations show the excellent reproducibility of repeated measurements at each standard level for both immunoassay systems. However, when using the TBA-25FR, it is necessary to perform measurements in the low-concentration range with care.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 38%
Other 2 25%
Researcher 2 25%
Student > Bachelor 1 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 25%
Chemistry 2 25%
Agricultural and Biological Sciences 1 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Medicine and Dentistry 1 13%
Other 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2016.
All research outputs
#3,145,644
of 7,546,003 outputs
Outputs from Journal of Pharmaceutical Health Care and Sciences
#7
of 34 outputs
Outputs of similar age
#111,820
of 279,937 outputs
Outputs of similar age from Journal of Pharmaceutical Health Care and Sciences
#3
of 4 outputs
Altmetric has tracked 7,546,003 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 34 research outputs from this source. They receive a mean Attention Score of 1.5. This one scored the same or higher as 27 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,937 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.