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Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy

Overview of attention for article published in Stem Cell Research & Therapy, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

twitter
14 tweeters
patent
2 patents
facebook
2 Facebook pages

Citations

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267 Dimensions

Readers on

mendeley
394 Mendeley
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Title
Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy
Published in
Stem Cell Research & Therapy, March 2016
DOI 10.1186/s13287-016-0303-6
Pubmed ID
Authors

Dylan E. Lee, Nagi Ayoub, Devendra K. Agrawal

Abstract

Mesenchymal stem cells (MSCs) (also known as multipotent mesenchymal stromal cells) possess the capacity for self-renewal and multi-lineage differentiation, and their ability to enhance cutaneous wound healing has been well characterized. Acting via paracrine interactions, MSCs accelerate wound closure, increase angiogenesis, promote resolution of wound inflammation, favorably regulate extracellular matrix remodeling, and encourage regeneration of skin with normal architecture and function. A number of studies have employed novel methods to amplify the delivery and efficacy of MSCs. Non-traditional sources of MSCs, including Wharton's jelly and medical waste material, have shown efficacy comparable to that of traditional sources, such as bone marrow and adipose tissue. The potential of alternative methods to both introduce MSCs into wounds and increase migration of MSCs into wound areas has also been demonstrated. Taking advantage of the associations between MSCs with M2 macrophages and microRNA, methods to enhance the immunomodulatory capacity of MSCs have shown success. New measures to enhance angiogenic capabilities have also exhibited effectiveness, often demonstrated by increased levels of proangiogenic vascular endothelial growth factor. Finally, hypoxia has been shown to have strong wound-healing potential in terms of increasing MSC efficacy. We have critically reviewed the results of the novel studies that show promise for the continued development of MSC-based wound-healing therapies and provide direction for continued research in this field.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 394 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
United Kingdom 1 <1%
Spain 1 <1%
Germany 1 <1%
Unknown 389 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 64 16%
Student > Bachelor 60 15%
Student > Ph. D. Student 48 12%
Researcher 42 11%
Student > Doctoral Student 22 6%
Other 76 19%
Unknown 82 21%
Readers by discipline Count As %
Medicine and Dentistry 80 20%
Biochemistry, Genetics and Molecular Biology 66 17%
Agricultural and Biological Sciences 43 11%
Engineering 17 4%
Pharmacology, Toxicology and Pharmaceutical Science 16 4%
Other 73 19%
Unknown 99 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2019.
All research outputs
#2,188,895
of 22,856,968 outputs
Outputs from Stem Cell Research & Therapy
#149
of 2,422 outputs
Outputs of similar age
#37,193
of 300,116 outputs
Outputs of similar age from Stem Cell Research & Therapy
#7
of 39 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,422 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,116 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.