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Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, March 2016
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Title
Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a randomized controlled trial
Published in
Trials, March 2016
DOI 10.1186/s13063-016-1275-7
Pubmed ID
Authors

Kathryn Eve Lewandowski, Sarah H. Sperry, Dost Ongur, Bruce M. Cohen, Lesley A. Norris, Matcheri S. Keshavan

Abstract

Cognitive dysfunction is a major feature of bipolar disorder with psychosis and is strongly associated with functional outcomes. Computer-based cognitive remediation has shown promise in improving cognition in patients with schizophrenia. However, despite similar neurocognitive deficits between patients with schizophrenia and bipolar disorder, few studies have extended neuroscience-based cognitive remediation programs to this population. The Treatment to Enhance Cognition in Bipolar Disorder study is an investigator-initiated, parallel group, randomized, blinded clinical trial of an Internet-based cognitive remediation protocol for patients with bipolar disorder I with psychosis (n = 100). We also describe the development of our dose-matched active control paradigm. Both conditions involve 70 sessions of computer-based activities over 24 weeks. The control intervention was developed to mirror the treatment condition in dose and format but without the neuroplasticity-based task design and structure. All participants undergo neuropsychological and clinical assessment at baseline, after approximately 25 hours of study activities, post treatment, and after 6 months of no study contact to assess durability. Neuroimaging at baseline and post treatment are offered in an "opt-in" format. The primary outcomes are scores on the MATRICS battery; secondary and exploratory outcomes include measures of clinical symptoms, community functioning, and neuroimaging changes. Associations between change in cognitive measures and change in community functioning will be assessed. Baseline predictors of treatment response will be examined. The present study is the first we are aware of to implement an Internet-based cognitive remediation program in patients with bipolar disorder with psychosis and to develop a comparable web-based control paradigm. The mixed online and study-site format allows accessible treatment while providing weekly staff contact and bridging. Based on user-provided feedback, participant blinding is feasible. ClinicalTrials.gov NCT01470781 ; 11 July 2011.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Colombia 1 <1%
South Africa 1 <1%
Unknown 188 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 29 15%
Researcher 28 15%
Student > Bachelor 21 11%
Student > Ph. D. Student 20 10%
Student > Doctoral Student 14 7%
Other 35 18%
Unknown 44 23%
Readers by discipline Count As %
Psychology 63 33%
Medicine and Dentistry 28 15%
Nursing and Health Professions 12 6%
Neuroscience 12 6%
Unspecified 9 5%
Other 17 9%
Unknown 50 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2016.
All research outputs
#5,328,703
of 7,386,232 outputs
Outputs from Trials
#1,520
of 2,043 outputs
Outputs of similar age
#179,096
of 276,558 outputs
Outputs of similar age from Trials
#90
of 122 outputs
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