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The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis

Overview of attention for article published in BMC Psychiatry, March 2016
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Title
The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis
Published in
BMC Psychiatry, March 2016
DOI 10.1186/s12888-016-0769-x
Pubmed ID
Authors

Erik Johnsen, Farivar Fathian, Rune A. Kroken, Vidar M. Steen, Hugo A. Jørgensen, Rolf Gjestad, Else-Marie Løberg

Abstract

Inflammatory processes have been implicated in the etiology of schizophrenia and related psychoses, in which cognitive deficits represent core symptoms. The aim of the present study was to investigate possible associations between the level of the inflammation marker C-reactive protein (CRP) and cognitive performance in patients through the acute phase of psychosis. A total of 124 patients were assessed at admittance to hospital and 62 patients were retested at discharge or after 6 weeks at the latest, with measurements of the CRP levels and alternative forms of the Repeatable Battery for the Assessment of Neuropsychological Status. There was an inverse relationship between overall cognitive performance and CRP level at admittance. The association increased in sub-analyses including only patients with schizophrenia. In cognitive subdomain analyses statistically significant inverse associations were found between the CRP level and Delayed memory and Attention, respectively. No associations were found between CRP level and other measures of psychopathology including psychosis symptoms, depression, or functioning. At follow-up the association between CRP level and cognition was no longer present. There was a significant increase in cognitive performance between baseline and follow-up. There was a stronger increase in overall cognition scores in patients with higher baseline CRP levels. The findings indicate that signs of inflammation may serve as a state-dependent marker of cognitive dysfunctions in acute psychosis. ClinicalTrials.gov ID; NCT00932529 , registration date: 02.07.2009.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 111 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 17%
Researcher 15 14%
Student > Master 14 13%
Student > Ph. D. Student 11 10%
Student > Postgraduate 8 7%
Other 20 18%
Unknown 24 22%
Readers by discipline Count As %
Psychology 22 20%
Medicine and Dentistry 21 19%
Neuroscience 11 10%
Agricultural and Biological Sciences 8 7%
Biochemistry, Genetics and Molecular Biology 6 5%
Other 10 9%
Unknown 33 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#13,972,009
of 22,856,968 outputs
Outputs from BMC Psychiatry
#2,944
of 4,698 outputs
Outputs of similar age
#153,126
of 299,541 outputs
Outputs of similar age from BMC Psychiatry
#59
of 92 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,698 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,541 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.