Title |
Study of Leishmania pathogenesis in mice: experimental considerations
|
---|---|
Published in |
Parasites & Vectors, March 2016
|
DOI | 10.1186/s13071-016-1413-9 |
Pubmed ID | |
Authors |
Corinne Loeuillet, Anne-Laure Bañuls, Mallorie Hide |
Abstract |
Although leishmaniases are endemic in 98 countries, they are still considered neglected tropical diseases. Leishmaniases are characterized by the emergence of new virulent and asymptomatic strains of Leishmania spp. and, as a consequence, by a very diverse clinical spectrum. To fight more efficiently these parasites, the mechanisms of host defense and of parasite virulence need to be thoroughly investigated. To this aim, animal models are widely used. However, the results obtained with these models are influenced by several experimental parameters, such as the mouse genetic background, parasite genotype, inoculation route/infection site, parasite dose and phlebotome saliva. In this review, we propose an update on their influence in the two main clinical forms of the disease: cutaneous and visceral leishmaniases. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Sri Lanka | 1 | <1% |
France | 1 | <1% |
Unknown | 283 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 39 | 14% |
Student > Master | 39 | 14% |
Student > Bachelor | 35 | 12% |
Student > Doctoral Student | 20 | 7% |
Other | 47 | 16% |
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Other | 34 | 12% |
Unknown | 82 | 29% |