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Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB

Overview of attention for article published in Journal of Neuroinflammation, February 2012
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Citations

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Title
Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB
Published in
Journal of Neuroinflammation, February 2012
DOI 10.1186/1742-2094-9-39
Pubmed ID
Authors

Sen Lin, Yajie Liang, Jiqiang Zhang, Chen Bian, Hongli Zhou, Qiang Guo, Ying Xiong, Shurong Li, Bingyin Su

Abstract

TIR-domain-containing adapter-inducing interferon-β (TRIF) is the sole downstream adaptor of Toll-like receptor (TLR)3, which is one of the major signaling pathways in immune cells leading to neuroinflammation in the central nervous system. Overexpression of TRIF may lead to activation of inflammatory responses, and contribute to pathophysiological progression in both acute and chronic neurodegenerative retinal diseases. In the present study, was aimed to elucidate the contributions of TRIF to optic nerve (ON) regeneration and retinal ganglion cell (RGC) survival following injury to the ON, a widely studied model of central nervous system injury and of degenerative diseases such as glaucoma.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 17%
Student > Ph. D. Student 6 17%
Student > Bachelor 5 14%
Researcher 5 14%
Professor > Associate Professor 3 8%
Other 5 14%
Unknown 6 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 31%
Medicine and Dentistry 7 19%
Neuroscience 5 14%
Nursing and Health Professions 2 6%
Immunology and Microbiology 1 3%
Other 2 6%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2012.
All research outputs
#18,304,874
of 22,663,150 outputs
Outputs from Journal of Neuroinflammation
#2,045
of 2,604 outputs
Outputs of similar age
#120,873
of 155,587 outputs
Outputs of similar age from Journal of Neuroinflammation
#29
of 37 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,604 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,587 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.