Title |
Human basal body basics
|
---|---|
Published in |
Cilia, March 2016
|
DOI | 10.1186/s13630-016-0030-8 |
Pubmed ID | |
Authors |
Anastassiia Vertii, Hui-Fang Hung, Heidi Hehnly, Stephen Doxsey |
Abstract |
In human cells, the basal body (BB) core comprises a ninefold microtubule-triplet cylindrical structure. Distal and subdistal appendages are located at the distal end of BB, where they play indispensable roles in cilium formation and function. Most cells that arrest in the G0 stage of the cell cycle initiate BB docking at the plasma membrane followed by BB-mediated growth of a solitary primary cilium, a structure required for sensing the extracellular environment and cell signaling. In addition to the primary cilium, motile cilia are present in specialized cells, such as sperm and airway epithelium. Mutations that affect BB function result in cilia dysfunction. This can generate syndromic disorders, collectively called ciliopathies, for which there are no effective treatments. In this review, we focus on the features and functions of BBs and centrosomes in Homo sapiens. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Indonesia | 1 | <1% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 19 | 17% |
Researcher | 17 | 15% |
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Student > Doctoral Student | 6 | 5% |
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Neuroscience | 3 | 3% |
Other | 9 | 8% |
Unknown | 20 | 17% |