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Expression of circulating miR-486 and miR-150 in patients with acute myocardial infarction

Overview of attention for article published in BMC Cardiovascular Disorders, June 2015
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Title
Expression of circulating miR-486 and miR-150 in patients with acute myocardial infarction
Published in
BMC Cardiovascular Disorders, June 2015
DOI 10.1186/s12872-015-0042-0
Pubmed ID
Authors

Rui Zhang, Chao Lan, Hui Pei, Guoyu Duan, Li Huang, Li

Abstract

With its high morbidity and mortality, acute myocardial infarction (AMI) places a major burden on society and on individual patients. Correct, early correct diagnosis is crucial to the management of AMI. In this study, the expression of circulating miR-486 and miR-150 was investigated in AMI patients and the two miRNAs were evaluated as potential biomarkers for AMI. Plasma samples from 110 patients with AMI (65 patients with ST-segment elevation myocardial infarction (STEMI) and 45 patients with non-ST-segment elevation myocardial infarction (NSTEMI)) and 110 healthy adults were collected. Circulating levels of miR-486 and miR-150 were detected using quantitative real-time PCR in plasma samples. Results showed that the levels of miR-486 and miR-150 were significantly higher in AMI patients than in healthy controls. Receiver operating characteristic (ROC) curve analyses indicated that the two plasma miRNAs were of significant diagnostic value for AMI, especially NSTEMI. The combined ROC analysis revealed an AUC value of 0.771 in discriminating AMI patients from healthy controls and an AUC value of 0.845 in discriminating NSTEMI patients from healthy controls. Results indicated that the levels of circulating miR-486 and miR-150 are associated with AMI. They may be novel and powerful biomarkers for AMI, especially for NSTEMI.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Student > Bachelor 7 23%
Student > Master 3 10%
Researcher 3 10%
Professor 1 3%
Other 3 10%
Unknown 6 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 30%
Medicine and Dentistry 8 27%
Agricultural and Biological Sciences 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 8 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2016.
All research outputs
#5,603,198
of 7,406,294 outputs
Outputs from BMC Cardiovascular Disorders
#389
of 569 outputs
Outputs of similar age
#208,574
of 297,163 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#23
of 33 outputs
Altmetric has tracked 7,406,294 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 569 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.