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MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, March 2016
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1 tweeter

Citations

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Title
MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling
Published in
Journal of Experimental & Clinical Cancer Research, March 2016
DOI 10.1186/s13046-016-0323-1
Pubmed ID
Authors

Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang, Jin-Shui Zhu

Abstract

MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 25%
Other 1 8%
Student > Bachelor 1 8%
Student > Master 1 8%
Researcher 1 8%
Other 1 8%
Unknown 4 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 25%
Chemistry 2 17%
Nursing and Health Professions 1 8%
Medicine and Dentistry 1 8%
Agricultural and Biological Sciences 1 8%
Other 0 0%
Unknown 4 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2016.
All research outputs
#5,603,242
of 7,406,294 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#199
of 388 outputs
Outputs of similar age
#208,587
of 297,163 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#15
of 26 outputs
Altmetric has tracked 7,406,294 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 388 research outputs from this source. They receive a mean Attention Score of 1.5. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,163 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.