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Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design

Overview of attention for article published in Trials, March 2016
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Title
Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design
Published in
Trials, March 2016
DOI 10.1186/s13063-016-1261-0
Pubmed ID
Authors

Yun Ju Jun, Jinhee Lee, Sehee Hwang, Jung Hyun Kwak, Hyeon Yeong Ahn, Youn Kyung Bak, Jihoon Koh, Jong Ho Lee

Abstract

Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w). The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose:xylose = 10:1), 3.33 g (Test 2, sucrose:xylose = 15:1), or 2.5 g (Test 3, sucrose:xylose = 20:1) of D-xylose separated by a one-week interval. Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group. Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes. ClinicalTrials.gov identifier: NCT02654301 . Registered 12 January 2016.

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Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 23%
Student > Master 4 18%
Student > Ph. D. Student 3 14%
Student > Doctoral Student 1 5%
Lecturer > Senior Lecturer 1 5%
Other 2 9%
Unknown 6 27%
Readers by discipline Count As %
Medicine and Dentistry 4 18%
Biochemistry, Genetics and Molecular Biology 3 14%
Nursing and Health Professions 3 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Chemistry 2 9%
Other 1 5%
Unknown 7 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2016.
All research outputs
#6,412,282
of 7,408,484 outputs
Outputs from Trials
#1,851
of 2,050 outputs
Outputs of similar age
#236,457
of 279,899 outputs
Outputs of similar age from Trials
#115
of 121 outputs
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We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.