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IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells

Overview of attention for article published in Journal of Translational Medicine, March 2016
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Title
IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells
Published in
Journal of Translational Medicine, March 2016
DOI 10.1186/s12967-016-0833-9
Pubmed ID
Authors

Jing-kun Li, Lin Nie, Yun-peng Zhao, Yuan-qiang Zhang, Xiaoqing Wang, Shuai-shuai Wang, Yi Liu, Hua Zhao, Lei Cheng

Abstract

Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated and degenerated IVD tissues and acts as a regulator of disc inflammation. The objective of this study was to investigate the involvement of IL-17A in IVD inflammatory response and to explore the mechanisms underlying this response. Cells were isolated from nucleus pulposus (NP) tissues collected from patients undergoing surgeries for IVD degeneration. The concentrations of COX2 and PGE2, as well as of select proteins involved in the mitogen-activated protein kinase (MAPK)/activating protein-1 (AP-1) pathway, were quantified in NP cells after exposure to IL-17 with or without pretreatment with MAPK or AP-1 inhibitors. Our results showed that IL-17A increased COX2 expression and PGE2 production via the activation of MAPKs, including p38 kinase and Jun N-terminal kinase (JNK). Moreover, IL-17A-induced COX2 and PGE2 production was shown to rely on p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner. In summary, our results indicate that IL-17A enhances COX2 expression and PGE2 production via the p38/c-Fos and JNK/c-Jun signalling pathways in NP cells to mediate IVD inflammation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 17%
Other 6 15%
Student > Ph. D. Student 5 12%
Student > Bachelor 4 10%
Researcher 3 7%
Other 5 12%
Unknown 11 27%
Readers by discipline Count As %
Medicine and Dentistry 14 34%
Biochemistry, Genetics and Molecular Biology 7 17%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Veterinary Science and Veterinary Medicine 1 2%
Agricultural and Biological Sciences 1 2%
Other 5 12%
Unknown 11 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2016.
All research outputs
#3,807,018
of 7,408,484 outputs
Outputs from Journal of Translational Medicine
#949
of 1,707 outputs
Outputs of similar age
#151,731
of 279,899 outputs
Outputs of similar age from Journal of Translational Medicine
#44
of 74 outputs
Altmetric has tracked 7,408,484 research outputs across all sources so far. This one is in the 28th percentile – i.e., 28% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,707 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,899 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.