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A single oral dose of a polyglucosamine influences the bioavailability of [9-14C]-Oleic acid in adult female Göttingen minipigs

Overview of attention for article published in BMC Obesity, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#33 of 183)
  • High Attention Score compared to outputs of the same age (86th percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

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4 Dimensions

Readers on

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24 Mendeley
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Title
A single oral dose of a polyglucosamine influences the bioavailability of [9-14C]-Oleic acid in adult female Göttingen minipigs
Published in
BMC Obesity, March 2016
DOI 10.1186/s40608-016-0096-2
Pubmed ID
Authors

Nicole H. P. Cnubben, Shanti L. Tel, Marleen A. Hemmes, Astrid Langenkamp-Brand, Dimitri Grossouw, Harm T. Jansen, Bert T. H. J. de Bie

Abstract

Worldwide obesity has nearly doubled since 1980 and is a leading risk for global deaths, profoundly affecting morbidity, mortality, health-care costs, and professional and personal quality of life. Treatment of obesity and its consequences include lifestyle intervention, pharmacotherapy, and bariatric surgery. Polyglucosamines have been proposed as an alternative strategy for treating obesity, by reducing the amount of absorbed fat through interaction with dietary fat through various mechanisms. The objective of this study is to investigate the influence of polyglucosamine on the bioavailability of the model compound [9-(14)C]-oleic acid in female Göttingen minipigs. The study consisted of two treatment groups, each consisting of six adult female Göttingen minipigs with a catheterized vena jugularis to enable frequent blood sampling. One group served as the untreated group (control) and the other group was pre-treated with 2 tablets of 500 mg formoline L112. After 30 min, all animals were dosed orally with [9-(14)C]-oleic acid. Excreta and blood samples were collected for analysis of radioactivity from 48 h pre-dose up to 144 h post-dosing. At sacrifice, the liver and contents of the gastrointestinal tract were collected for radioanalysis. Upon treatment with polyglucosamine (formoline L112), the Tmax of [(14)C]-oleic acid in plasma was shifted from 4 to 16 h, and the Cmax decreased significantly from 14.1 μg/g to 3.3 μg/g. In addition, upon treatment with polyglucosamine the internal exposure to [(14)C]-oleic acid as reflected by the area under the curve during the 0-12 h post-dose time interval (AUC0-12h), is significantly decreased to 32.9 % of the plasma value of [(14)C]-oleic acid in untreated animals. Even up to 24 h post-dose, the AUC0-24h is significantly decreased to 50.7 % of the plasma value in untreated animals and this significant effect is prolonged up to 60 h post-dose. This study shows that treatment with polyglucosamine (formoline L112) reduces (as judged by Cmax & AUC) and delays (as judged by Tmax) fat absorption from the gastrointestinal tract into the systemic circulation and limits peak exposure to free fatty acids which may contribute to a more beneficial condition in overweight humans.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 17%
Student > Doctoral Student 3 13%
Student > Master 3 13%
Student > Ph. D. Student 3 13%
Other 2 8%
Other 4 17%
Unknown 5 21%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 17%
Medicine and Dentistry 2 8%
Agricultural and Biological Sciences 2 8%
Sports and Recreations 2 8%
Nursing and Health Professions 1 4%
Other 5 21%
Unknown 8 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2020.
All research outputs
#1,815,284
of 17,635,820 outputs
Outputs from BMC Obesity
#33
of 183 outputs
Outputs of similar age
#36,550
of 272,553 outputs
Outputs of similar age from BMC Obesity
#1
of 1 outputs
Altmetric has tracked 17,635,820 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 183 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,553 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them