Title |
From bench to bedside a comprehensive review of pancreatic cancer immunotherapy
|
---|---|
Published in |
Journal for Immunotherapy of Cancer, March 2016
|
DOI | 10.1186/s40425-016-0119-z |
Pubmed ID | |
Authors |
Paul R. Kunk, Todd W. Bauer, Craig L. Slingluff, Osama E. Rahma |
Abstract |
The incidence of pancreatic cancer has been increasing while its 5-year survival rate has not changed in decades. In the era of personalized medicine, immunotherapy has emerged as a promising treatment modality in a variety of malignancies, including pancreatic cancer. This review will discuss the unique pancreatic tumor microenvironment, including the cells and receptors that transform the pancreas from its normal architecture into a complex mix of suppressor immune cells and dense extracellular matrix that allows for the unrestricted growth of cancer cells. Next, we will highlight the recently completed immunotherapy clinical trials in pancreatic cancer. Finally, we will explore the on-going immunotherapy clinical trials and future directions of this engaging and changing field. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 65% |
Canada | 2 | 12% |
United Kingdom | 1 | 6% |
Unknown | 3 | 18% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 65% |
Scientists | 3 | 18% |
Practitioners (doctors, other healthcare professionals) | 2 | 12% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Korea, Republic of | 1 | <1% |
Unknown | 164 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 19% |
Researcher | 31 | 18% |
Other | 15 | 9% |
Student > Doctoral Student | 14 | 8% |
Student > Master | 14 | 8% |
Other | 33 | 20% |
Unknown | 29 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 30% |
Biochemistry, Genetics and Molecular Biology | 26 | 15% |
Agricultural and Biological Sciences | 23 | 14% |
Immunology and Microbiology | 12 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
Other | 17 | 10% |
Unknown | 32 | 19% |