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Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

Overview of attention for article published in Skeletal Muscle, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)

Mentioned by

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18 tweeters
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3 Facebook pages

Citations

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21 Dimensions

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59 Mendeley
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Title
Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
Published in
Skeletal Muscle, March 2016
DOI 10.1186/s13395-016-0084-8
Pubmed ID
Authors

Maitea Guridi, Barbara Kupr, Klaas Romanino, Shuo Lin, Denis Falcetta, Lionel Tintignac, Markus A. Rüegg

Abstract

The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pathways controlling cell growth and survival. This multiprotein complex integrates external signals and affects different nutrient pathways in various organs. However, it is not clear how alterations of mTORC1 signaling in skeletal muscle affect whole-body metabolism. We characterized the metabolic phenotype of young and old raptor muscle knock-out (RAmKO) and TSC1 muscle knock-out (TSCmKO) mice, where mTORC1 activity in skeletal muscle is inhibited or constitutively activated, respectively. Ten-week-old RAmKO mice are lean and insulin resistant with increased energy expenditure, and they are resistant to a high-fat diet (HFD). This correlates with an increased expression of histone deacetylases (HDACs) and a downregulation of genes involved in glucose and fatty acid metabolism. Ten-week-old TSCmKO mice are also lean, glucose intolerant with a decreased activation of protein kinase B (Akt/PKB) targets that regulate glucose transporters in the muscle. The mice are resistant to a HFD and show reduced accumulation of glycogen and lipids in the liver. Both mouse models suffer from a myopathy with age, with reduced fat and lean mass, and both RAmKO and TSCmKO mice develop insulin resistance and increased intramyocellular lipid content. Our study shows that alterations of mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. While both inhibition and constitutive activation of mTORC1 induce leanness and resistance to obesity, changes in the metabolism of muscle and peripheral organs are distinct. These results indicate that a balanced mTORC1 signaling in the muscle is required for proper metabolic homeostasis.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
Netherlands 1 2%
Chile 1 2%
New Zealand 1 2%
United States 1 2%
Unknown 53 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 25%
Student > Master 12 20%
Student > Ph. D. Student 9 15%
Student > Bachelor 4 7%
Other 4 7%
Other 5 8%
Unknown 10 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 31%
Medicine and Dentistry 11 19%
Sports and Recreations 7 12%
Agricultural and Biological Sciences 4 7%
Nursing and Health Professions 2 3%
Other 4 7%
Unknown 13 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2016.
All research outputs
#2,298,306
of 17,035,895 outputs
Outputs from Skeletal Muscle
#66
of 310 outputs
Outputs of similar age
#47,509
of 270,756 outputs
Outputs of similar age from Skeletal Muscle
#1
of 1 outputs
Altmetric has tracked 17,035,895 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 310 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,756 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them