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X Demographics
Mendeley readers
| Title |
Early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury (The ELAIN-Trial): study protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, March 2016
|
| DOI | 10.1186/s13063-016-1249-9 |
| Pubmed ID | |
| Authors |
Alexander Zarbock, Joachim Gerß, Hugo Van Aken, Andreea Boanta, John A. Kellum, Melanie Meersch |
| Abstract |
Acute kidney injury remains a common complication in critically ill patients and despite multiple trials and observational studies, the optimal timing for initiation of renal replacement therapy is still unclear. The early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury (ELAIN) study is a randomized, single-center, prospective, two-arm, parallel group trial to reduce mortality in patients with severe acute kidney injury. We describe the study design and discuss aspects of the need for a trial in this patient cohort. Our plan is to randomize critically ill patients with acute kidney injury to 'early' or 'late' initiation of renal replacement therapy according to stage 2 and 3 of the KDIGO classification using a specific trial protocol. We plan to guide data collection and analysis using pre-existing definitions and testing. The primary endpoint is overall survival in a 90-day follow-up period. Secondary endpoints include 28-day, 60-day, 90-day and 1-year all-cause mortality, recovery of renal function, ICU and hospital length-of-stay. The primary analysis will be an intention-to-treat analysis; secondary analyses include treated analyses. We will also specify rules for handling data and determining outcome. Several challenges for study design and execution can be seen in our trial, and it should generate results that will inform and influence the practice of renal replacement therapy in critically ill patients with acute kidney injury. German Clinical Trials Register: DRKS00004367 ( www.germanctr.de ); 28 May 2013. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 50% |
| Indonesia | 1 | 13% |
| United Kingdom | 1 | 13% |
| Argentina | 1 | 13% |
| Unknown | 1 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Unknown | 104 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 13% |
| Student > Master | 13 | 12% |
| Student > Postgraduate | 12 | 11% |
| Student > Bachelor | 12 | 11% |
| Student > Ph. D. Student | 10 | 10% |
| Other | 21 | 20% |
| Unknown | 23 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 51 | 49% |
| Nursing and Health Professions | 9 | 9% |
| Engineering | 5 | 5% |
| Computer Science | 2 | 2% |
| Mathematics | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 29 | 28% |