Title |
Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
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Published in |
BMC Neuroscience, March 2012
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DOI | 10.1186/1471-2202-13-24 |
Pubmed ID | |
Authors |
Luciana Sayuri Sanada, Andréa Lurdes da Rocha Kalil, Marcelo Rodrigo Tavares, Milena Cardoso Maia Neubern, Helio Cesar Salgado, Valéria Paula Sassoli Fazan |
Abstract |
The sural nerve has been widely investigated in experimental models of neuropathies but information about its involvement in hypertension was not yet explored. The aim of the present study was to compare the morphological and morphometric aspects of different segments of the sural nerve in male and female spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. Rats aged 20 weeks (N = 6 in each group) were investigated. After arterial pressure and heart rate recordings in anesthetized animals, right and left sural nerves were removed and prepared for epoxy resin embedding and light microscopy. Morphometric analysis was performed with the aid of computer software, and took into consideration the fascicle area and diameter, as well as myelinated fiber number, density, area and diameter. |
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