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Role of dendritic cells in the induction of regulatory T cells

Overview of attention for article published in Cell & Bioscience, May 2011
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1 X user

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Title
Role of dendritic cells in the induction of regulatory T cells
Published in
Cell & Bioscience, May 2011
DOI 10.1186/2045-3701-1-20
Pubmed ID
Authors

Rahul Kushwah, Jim Hu

Abstract

Dendritic cells (DCs) play a key role in initiating immune responses and maintaining immune tolerance. In addition to playing a role in thymic selection, DCs play an active role in tolerance under steady state conditions through several mechanisms which are dependent on IL-10, TGF-β, retinoic acid, indoleamine-2,3,-dioxygenase along with vitamin D. Several of these mechanisms are employed by DCs in induction of regulatory T cells which are comprised of Tr1 regulatory T cells, natural and inducible foxp3+ regulatory T cells, Th3 regulatory T cells and double negative regulatory T cells. It appears that certain DC subsets are highly specialized in inducing regulatory T cell differentiation and in some tissues the local microenvironment plays a role in driving DCs towards a tolerogenic response. In this review we discuss the recent advances in our understanding of the mechanisms underlying DC driven regulatory T cell induction.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Turkey 1 <1%
Indonesia 1 <1%
Ireland 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Japan 1 <1%
United States 1 <1%
Other 1 <1%
Unknown 205 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 57 27%
Student > Bachelor 33 15%
Student > Master 30 14%
Researcher 25 12%
Student > Doctoral Student 9 4%
Other 29 13%
Unknown 32 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 84 39%
Immunology and Microbiology 32 15%
Medicine and Dentistry 31 14%
Biochemistry, Genetics and Molecular Biology 13 6%
Nursing and Health Professions 2 <1%
Other 11 5%
Unknown 42 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2012.
All research outputs
#15,242,272
of 22,663,150 outputs
Outputs from Cell & Bioscience
#378
of 914 outputs
Outputs of similar age
#83,838
of 111,886 outputs
Outputs of similar age from Cell & Bioscience
#2
of 2 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 914 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,886 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.