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Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus

Overview of attention for article published in Cardiovascular Diabetology, March 2016
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2 tweeters

Citations

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105 Dimensions

Readers on

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99 Mendeley
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Title
Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus
Published in
Cardiovascular Diabetology, March 2016
DOI 10.1186/s12933-016-0367-8
Pubmed ID
Authors

Felix Jansen, Han Wang, David Przybilla, Bernardo S. Franklin, Andreas Dolf, Philipp Pfeifer, Theresa Schmitz, Anna Flender, Elmar Endl, Georg Nickenig, Nikos Werner

Abstract

Circulating microRNAs (miRs) are differentially regulated and selectively packaged into microparticles (MPs). We evaluated whether diabetes mellitus alters circulating vascular and endothelial MP-incorporated miRs expression levels. Circulating MPs were isolated from 135 patients with or without diabetes mellitus type II and characterized using flow cytometer and electron microscope. Nine miRs involved in the regulation of vascular performance-miR-126, miR-222, miR-let7d, miR-21, miR-30, miR-92a, miR-139, miR-199a and miR-26a-were quantified in circulating MPs by reverse transcription polymerase chain reaction. Among those, miR-126 and miR-26a were significantly reduced in diabetic patients compared to non-diabetic patients. Patients with low miR-26a and miR-126 levels were at higher risk for a concomitant coronary artery disease. MP-sorting experiments showed that endothelial cells were the major cell sources of MPs containing miR-126 and miR-26a, respectively. Finally, in accordance with our clinical results, in vitro experiments revealed that hyperglycemia reduces the packaging of miR-126 and miR-26a into EMPs. Diabetes mellitus significantly alters the expression of vascular endothelial miRs in circulating endothelial MPs with potential implications on vascular heath.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 99 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 23%
Researcher 15 15%
Student > Bachelor 15 15%
Student > Master 14 14%
Student > Doctoral Student 7 7%
Other 12 12%
Unknown 13 13%
Readers by discipline Count As %
Medicine and Dentistry 32 32%
Biochemistry, Genetics and Molecular Biology 19 19%
Agricultural and Biological Sciences 13 13%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Nursing and Health Professions 3 3%
Other 6 6%
Unknown 23 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2016.
All research outputs
#15,365,885
of 22,858,915 outputs
Outputs from Cardiovascular Diabetology
#840
of 1,383 outputs
Outputs of similar age
#179,976
of 300,114 outputs
Outputs of similar age from Cardiovascular Diabetology
#24
of 30 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,383 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,114 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.