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Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3

Overview of attention for article published in BMC Medical Genomics, March 2012
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Title
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3
Published in
BMC Medical Genomics, March 2012
DOI 10.1186/1471-2350-13-12
Pubmed ID
Authors

Madhushika Ratnayake, Louise N Reynard, Emma VA Raine, Mauro Santibanez-Koref, John Loughlin

Abstract

A genome-wide association scan with subsequent replication study that involved over 67,000 individuals of European ancestry has produced evidence of association of single nucleotide polymorphism rs2277831 to primary osteoarthritis (OA) with a P-value of 2.9 × 10(-5). rs2277831, an A/G transition, is located in an intron of MICAL3. This gene is located on chromosome 22q11.21 and the association signal encompasses two additional genes, BCL2L13 and BID. It is becoming increasingly apparent that many common complex traits are mediated by cis-acting regulatory polymorphisms that influence, in a tissue-specific manner, gene expression or transcript stability.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 30%
Student > Ph. D. Student 4 20%
Lecturer > Senior Lecturer 2 10%
Other 2 10%
Student > Master 2 10%
Other 2 10%
Unknown 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 30%
Medicine and Dentistry 5 25%
Biochemistry, Genetics and Molecular Biology 3 15%
Nursing and Health Professions 1 5%
Computer Science 1 5%
Other 1 5%
Unknown 3 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2012.
All research outputs
#15,169,949
of 25,374,917 outputs
Outputs from BMC Medical Genomics
#978
of 2,444 outputs
Outputs of similar age
#97,937
of 168,384 outputs
Outputs of similar age from BMC Medical Genomics
#8
of 23 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,444 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,384 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.