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The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

Overview of attention for article published in BMC Cancer, March 2016
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Title
The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis
Published in
BMC Cancer, March 2016
DOI 10.1186/s12885-016-2276-3
Pubmed ID
Authors

Guanghua Li, Zhao Wang, Jianbo Xu, Hui Wu, Shirong Cai, Yulong He

Abstract

The prognostic value of lactate dehydrogenase levels in the prognosis of colorectal cancer patients has been assessed for years, although the results remain controversial and heterogeneous. Thus, we comprehensively reviewed the evidence from studies that evaluated lactate dehydrogenase levels in colorectal cancer patients to determine their effect. The following databases were searched in September 2014 to identify studies that evaluated the prognostic value of lactate dehydrogenase levels in colorectal cancer: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. We extracted hazard ratios (HRs) and the associated 95 % confidence intervals (CIs) from the identified studies, and performed random-effects model meta-analyses on the overall survival (OS) and progression-free survival (PFS). Thirty-two studies with a cumulative sample size of 8,261 patients were included in our analysis. Our meta-analyses revealed that high levels of lactate dehydrogenase were associated with poor OS (HR, 1.75; 95 % CI, 1.52-2.02) in colorectal cancer patients. However, this effect was not obvious in the OS of non-metastatic colorectal cancer patients (HR, 1.21; 95 % CI, 0.79-1.86). The prognostic value of lactate dehydrogenase levels on PFS was also not confirmed (HR, 1.36; 95 % CI, 0.98-1.87). Subgroup analyses revealed that the prognostic significance of lactate dehydrogenase was independent of study location, patient age, number of patients, metastasis, chemotherapy with anti-angiogenesis drugs, study type, or risk of bias. Our results indicate that high lactate dehydrogenase levels are associated with poor OS among colorectal cancer patients, although these levels are not significant predictors of PFS.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 18%
Researcher 7 18%
Student > Bachelor 5 13%
Student > Ph. D. Student 5 13%
Student > Doctoral Student 3 8%
Other 5 13%
Unknown 8 20%
Readers by discipline Count As %
Medicine and Dentistry 18 45%
Biochemistry, Genetics and Molecular Biology 7 18%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Nursing and Health Professions 2 5%
Unspecified 1 3%
Other 2 5%
Unknown 8 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2016.
All research outputs
#6,442,904
of 7,438,587 outputs
Outputs from BMC Cancer
#2,675
of 3,256 outputs
Outputs of similar age
#233,453
of 275,776 outputs
Outputs of similar age from BMC Cancer
#125
of 158 outputs
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