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Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

Overview of attention for article published in Biology Direct, March 2016
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2 tweeters

Citations

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14 Dimensions

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55 Mendeley
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Title
Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics
Published in
Biology Direct, March 2016
DOI 10.1186/s13062-016-0117-6
Pubmed ID
Authors

Lae U. Kim, Maria R. D’Orsogna, Tom Chou

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that regulates numerous physiological processes. Disruptions in the activity of the HPA axis are correlated with stress-related diseases such as post-traumatic stress disorder (PTSD) and major depressive disorder. In this paper, we characterize "normal" and "diseased" states of the HPA axis as basins of attraction of a dynamical system describing the inhibition of peptide hormones such as corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) by circulating glucocorticoids such as cortisol (CORT). In addition to including key physiological features such as ultradian oscillations in cortisol levels and self-upregulation of CRH neuron activity, our model distinguishes the relatively slow process of cortisol-mediated CRH biosynthesis from rapid trans-synaptic effects that regulate the CRH secretion process. We show that the slow component of the negative feedback allows external stress-induced reversible transitions between "normal" and "diseased" states in novel intensity-, duration-, and timing-dependent ways. Our two-step negative feedback model suggests a mechanism whereby exposure therapy of stress disorders such as PTSD may act to normalize downstream dysregulation of the HPA axis. Our analysis provides a causative rationale for improving treatments and guiding the design of new protocols. This article was reviewed by Dr. Daniel Coombs, Dr. Yang Kuang, and Dr. Ha Youn Lee.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 13%
Other 6 11%
Student > Bachelor 6 11%
Researcher 6 11%
Student > Master 6 11%
Other 9 16%
Unknown 15 27%
Readers by discipline Count As %
Psychology 8 15%
Medicine and Dentistry 5 9%
Agricultural and Biological Sciences 4 7%
Neuroscience 4 7%
Physics and Astronomy 4 7%
Other 13 24%
Unknown 17 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2016.
All research outputs
#13,109,576
of 20,370,630 outputs
Outputs from Biology Direct
#351
of 571 outputs
Outputs of similar age
#153,278
of 279,063 outputs
Outputs of similar age from Biology Direct
#4
of 4 outputs
Altmetric has tracked 20,370,630 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 571 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,063 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.