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A heat-inactivated H7N3 vaccine induces cross-reactive cellular immunity in HLA-A2.1 transgenic mice

Overview of attention for article published in Virology Journal, March 2016
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  • Good Attention Score compared to outputs of the same age (68th percentile)

Mentioned by

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2 tweeters
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1 patent
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1 Facebook page

Citations

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7 Dimensions

Readers on

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12 Mendeley
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Title
A heat-inactivated H7N3 vaccine induces cross-reactive cellular immunity in HLA-A2.1 transgenic mice
Published in
Virology Journal, March 2016
DOI 10.1186/s12985-016-0513-7
Pubmed ID
Authors

Giuseppina Di Mario, Bruno Garulli, Ester Sciaraffia, Marzia Facchini, Isabella Donatelli, Maria R. Castrucci

Abstract

Cross-reactive immunity against heterologous strains of influenza virus has the potential to provide partial protection in individuals that lack the proper neutralizing antibodies. In particular, the boosting of memory CD8+ T cell responses to conserved viral proteins can attenuate disease severity caused by influenza virus antigenic variants or pandemic strains. However, little is yet known about which of these conserved internal antigens would better induce and/or recall memory CD8+ T cells after in vivo administration of an inactivated whole virus vaccine. We explored the CD8 + T cell responses to selected epitopes of the internal proteins of an H7N3 influenza virus that were cross-reactive with A/PR/8/34 virus in HLA-A2.1 transgenic (AAD) mice. CD8+ T cells against dominant and subdominant epitopes were detected upon infection of mice with live H7N3 virus, whereas immunization with non-replicating virus elicited CD8+ T cell responses against mostly immunodominant epitopes, which were rapidly recalled following infection with A/PR/8/34 virus. These vaccine-induced T cell responses were able to reduce the lung viral load in mice challenged intranasally with the heterologous influenza virus. A single immunization with non-replicating influenza virus vaccines may be able to elicit or recall cross-reactive CD8+ T cell responses to conserved immunodominant epitopes and, to some extent, counteract an infection by heterologous virus.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 33%
Other 2 17%
Student > Master 2 17%
Student > Doctoral Student 1 8%
Unknown 3 25%
Readers by discipline Count As %
Medicine and Dentistry 3 25%
Biochemistry, Genetics and Molecular Biology 2 17%
Agricultural and Biological Sciences 1 8%
Environmental Science 1 8%
Immunology and Microbiology 1 8%
Other 1 8%
Unknown 3 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2021.
All research outputs
#5,716,652
of 20,420,776 outputs
Outputs from Virology Journal
#605
of 2,837 outputs
Outputs of similar age
#84,361
of 278,236 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 20,420,776 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,837 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,236 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them