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Expression profile of androgen-modulated microRNAs in the fetal murine lung

Overview of attention for article published in Biology of Sex Differences, April 2016
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Title
Expression profile of androgen-modulated microRNAs in the fetal murine lung
Published in
Biology of Sex Differences, April 2016
DOI 10.1186/s13293-016-0072-z
Pubmed ID
Authors

Wafae Bouhaddioui, Pierre R. Provost, Yves Tremblay

Abstract

Androgens are known to delay lung development. As a consequence, the incidence and morbidity of respiratory distress syndrome of the neonate are higher for male than for female premature infants. We previously reported that many genes were expressed with a sex difference in the mouse developing lung and that several genes were under the control of androgens in the male fetal lung. microRNAs are small non-coding RNAs known to negatively regulate the expression of specific genes. In this study, we examined whether murine miRNAs are under the control of androgens in the male developing lung. Expression profiling of microRNAs was performed by microarrays using RNA extracted from male fetal lungs isolated on gestational day (GD) 17.0 and GD 18.0 after daily injection of pregnant mice from GD 10.0 with the antiandrogen flutamide or vehicle only. To identify putative miRNA target genes, the data obtained here were combined with gene profiling data reported previously using the same RNA preparations. qPCR was used to confirm microarray data with fetal lungs from other litters than those used in microarrays. Flutamide induced downregulation and upregulation of several miRNAs on GD 17.0 and GD 18.0. Of the 43 mature miRNAs modulated by flutamide on GD 17.0, 60 % were downregulated, whereas this proportion was only of 34 % for the 35 mature miRNAs modulated on GD 18.0. For 29 and 26 flutamide-responsive miRNAs, we found a corresponding target inversely regulated by androgens on GD 17.0 and 18.0, respectively. The androgen-regulated target genes were involved in several biological processes (lipid metabolism, cell proliferation, and lung development) and molecular functions, mainly transcription factor binding. Regulation of male lung development involves several miRNAs that are under androgen modulation in vivo.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 26%
Student > Bachelor 5 19%
Student > Master 4 15%
Researcher 4 15%
Other 2 7%
Other 2 7%
Unknown 3 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 22%
Medicine and Dentistry 6 22%
Biochemistry, Genetics and Molecular Biology 4 15%
Psychology 3 11%
Nursing and Health Professions 2 7%
Other 0 0%
Unknown 6 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2016.
All research outputs
#17,796,099
of 22,860,626 outputs
Outputs from Biology of Sex Differences
#403
of 474 outputs
Outputs of similar age
#205,825
of 300,229 outputs
Outputs of similar age from Biology of Sex Differences
#9
of 10 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
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