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Following Ariadne's thread: a new perspective on RBR ubiquitin ligases

Overview of attention for article published in BMC Biology, March 2012
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2 tweeters

Citations

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67 Dimensions

Readers on

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100 Mendeley
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Title
Following Ariadne's thread: a new perspective on RBR ubiquitin ligases
Published in
BMC Biology, March 2012
DOI 10.1186/1741-7007-10-24
Pubmed ID
Authors

Dawn M Wenzel, Rachel E Klevit

Abstract

Ubiquitin signaling pathways rely on E3 ligases for effecting the final transfer of ubiquitin from E2 ubiquitin conjugating enzymes to a protein target. Here we re-evaluate the hybrid RING/HECT mechanism used by the E3 family RING-between-RINGs (RBRs) to transfer ubiquitin to substrates. We place RBRs into the context of current knowledge of HECT and RING E3s. Although not as abundant as the other types of E3s (there are only slightly more than a dozen RBR E3s in the human genome), RBRs are conserved in all eukaryotes and play important roles in biology. Re-evaluation of RBR ligases as RING/HECT E3s provokes new questions and challenges the field.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Chile 1 1%
Japan 1 1%
Germany 1 1%
Unknown 95 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 31%
Researcher 14 14%
Student > Master 13 13%
Student > Bachelor 11 11%
Student > Doctoral Student 5 5%
Other 14 14%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 45%
Biochemistry, Genetics and Molecular Biology 30 30%
Chemistry 3 3%
Arts and Humanities 2 2%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 6 6%
Unknown 12 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2012.
All research outputs
#9,553,618
of 12,434,754 outputs
Outputs from BMC Biology
#1,018
of 1,120 outputs
Outputs of similar age
#79,140
of 116,616 outputs
Outputs of similar age from BMC Biology
#10
of 11 outputs
Altmetric has tracked 12,434,754 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,120 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,616 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.