Title |
Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families
|
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Published in |
BMC Cancer, March 2012
|
DOI | 10.1186/1471-2407-12-84 |
Pubmed ID | |
Authors |
Juana Fernández-Rodríguez, Francisco Quiles, Ignacio Blanco, Alex Teulé, Lídia Feliubadaló, Jesús del Valle, Mónica Salinas, Àngel Izquierdo, Esther Darder, Detlev Schindler, Gabriel Capellá, Joan Brunet, Conxi Lázaro, Miguel Angel Pujana |
Abstract |
Genes that, when mutated, cause Fanconi anemia or greatly increase breast cancer risk encode for proteins that converge on a homology-directed DNA damage repair process. Mutations in the SLX4 gene, which encodes for a scaffold protein involved in the repair of interstrand cross-links, have recently been identified in unclassified Fanconi anemia patients. A mutation analysis of SLX4 in German or Byelorussian familial cases of breast cancer without detected mutations in BRCA1 or BRCA2 has been completed, with globally negative results. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 8 | 23% |
Student > Ph. D. Student | 7 | 20% |
Researcher | 6 | 17% |
Student > Master | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 3 | 9% |
Unknown | 6 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 34% |
Agricultural and Biological Sciences | 11 | 31% |
Medicine and Dentistry | 4 | 11% |
Computer Science | 1 | 3% |
Engineering | 1 | 3% |
Other | 0 | 0% |
Unknown | 6 | 17% |