Title |
Increased levels of prolactin receptor expression correlate with the early onset of lupus symptoms and increased numbers of transitional-1 B cells after prolactin treatment
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Published in |
BMC Immunology, March 2012
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DOI | 10.1186/1471-2172-13-11 |
Pubmed ID | |
Authors |
Yadira Ledesma-Soto, Francisco Blanco-Favela, Ezequiel M Fuentes-Pananá, Emiliano Tesoro-Cruz, Rafael Hernández-González, Lourdes Arriaga-Pizano, María V Legorreta-Haquet, Eduardo Montoya-Diaz, Luis Chávez-Sánchez, María E Castro-Mussot, Adriana K Chávez-Rueda |
Abstract |
Prolactin is secreted from the pituitary gland and other organs, as well as by cells such as lymphocytes. Prolactin has an immunostimulatory effect and is associated with autoimmune diseases that are characterised by abnormal B cell activation, such as systemic lupus erythematosus (SLE). Our aim was to determine if different splenic B cell subsets express the prolactin receptor and if the presence of prolactin influences these B cell subsets and correlates with development of lupus. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 19% |
Researcher | 3 | 12% |
Student > Bachelor | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 5 | 19% |
Unknown | 7 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 23% |
Medicine and Dentistry | 6 | 23% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Nursing and Health Professions | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 8% |
Unknown | 7 | 27% |