Title |
Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis
|
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Published in |
Journal of Translational Medicine, April 2009
|
DOI | 10.1186/1479-5876-7-29 |
Pubmed ID | |
Authors |
Neil H Riordan, Thomas E Ichim, Wei-Ping Min, Hao Wang, Fabio Solano, Fabian Lara, Miguel Alfaro, Jorge Paz Rodriguez, Robert J Harman, Amit N Patel, Michael P Murphy, Roland R Lee, Boris Minev |
Abstract |
The stromal vascular fraction (SVF) of adipose tissue is known to contain mesenchymal stem cells (MSC), T regulatory cells, endothelial precursor cells, preadipocytes, as well as anti-inflammatory M2 macrophages. Safety of autologous adipose tissue implantation is supported by extensive use of this procedure in cosmetic surgery, as well as by ongoing studies using in vitro expanded adipose derived MSC. Equine and canine studies demonstrating anti-inflammatory and regenerative effects of non-expanded SVF cells have yielded promising results. Although non-expanded SVF cells have been used successfully in accelerating healing of Crohn's fistulas, to our knowledge clinical use of these cells for systemic immune modulation has not been reported. In this communication we discuss the rationale for use of autologous SVF in treatment of multiple sclerosis and describe our experiences with three patients. Based on this rationale and initial experiences, we propose controlled trials of autologous SVF in various inflammatory conditions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 8 | 62% |
Panama | 1 | 8% |
Unknown | 4 | 31% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 77% |
Scientists | 2 | 15% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | <1% |
Spain | 2 | <1% |
United States | 2 | <1% |
China | 1 | <1% |
Korea, Republic of | 1 | <1% |
Japan | 1 | <1% |
Taiwan | 1 | <1% |
Unknown | 273 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 48 | 17% |
Student > Master | 37 | 13% |
Student > Ph. D. Student | 31 | 11% |
Student > Bachelor | 27 | 10% |
Other | 25 | 9% |
Other | 54 | 19% |
Unknown | 61 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 79 | 28% |
Agricultural and Biological Sciences | 53 | 19% |
Biochemistry, Genetics and Molecular Biology | 31 | 11% |
Immunology and Microbiology | 9 | 3% |
Veterinary Science and Veterinary Medicine | 9 | 3% |
Other | 30 | 11% |
Unknown | 72 | 25% |