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Regulation of G protein-coupled receptors by palmitoylation and cholesterol

Overview of attention for article published in BMC Biology, March 2012
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Title
Regulation of G protein-coupled receptors by palmitoylation and cholesterol
Published in
BMC Biology, March 2012
DOI 10.1186/1741-7007-10-27
Pubmed ID
Authors

Alan D Goddard, Anthony Watts

Abstract

Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 3%
Portugal 1 <1%
Austria 1 <1%
Denmark 1 <1%
United Kingdom 1 <1%
Spain 1 <1%
Poland 1 <1%
Unknown 143 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 25%
Researcher 27 18%
Student > Bachelor 18 12%
Student > Master 16 10%
Student > Doctoral Student 9 6%
Other 24 16%
Unknown 21 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 59 38%
Biochemistry, Genetics and Molecular Biology 34 22%
Chemistry 10 6%
Pharmacology, Toxicology and Pharmaceutical Science 8 5%
Medicine and Dentistry 8 5%
Other 8 5%
Unknown 27 18%