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Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

Overview of attention for article published in BMC Genomics, March 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

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1 X user
patent
1 patent

Citations

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39 Dimensions

Readers on

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53 Mendeley
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2 CiteULike
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Title
Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria
Published in
BMC Genomics, March 2012
DOI 10.1186/1471-2164-13-106
Pubmed ID
Authors

Katarzyna Kinga Modrzynska, Alison Creasey, Laurence Loewe, Timothee Cezard, Sofia Trindade Borges, Axel Martinelli, Louise Rodrigues, Pedro Cravo, Mark Blaxter, Richard Carter, Paul Hunt

Abstract

Drug resistance in the malaria parasite Plasmodium falciparum severely compromises the treatment and control of malaria. A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of drug action and mechanisms of resistances. They are required to design better therapies and limit drug resistance.A mutation in the gene (pfcrt) encoding a membrane transporter has been identified as a principal determinant of chloroquine resistance in P. falciparum, but we lack a full account of higher level chloroquine resistance. Furthermore, the determinants of resistance in the other major human malaria parasite, P. vivax, are not known. To address these questions, we investigated the genetic basis of chloroquine resistance in an isogenic lineage of rodent malaria parasite P. chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
United States 2 4%
Indonesia 1 2%
India 1 2%
Unknown 47 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 25%
Researcher 10 19%
Student > Master 6 11%
Other 5 9%
Student > Bachelor 3 6%
Other 10 19%
Unknown 6 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 40%
Biochemistry, Genetics and Molecular Biology 9 17%
Medicine and Dentistry 7 13%
Immunology and Microbiology 3 6%
Chemistry 3 6%
Other 2 4%
Unknown 8 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2018.
All research outputs
#6,378,772
of 22,663,969 outputs
Outputs from BMC Genomics
#2,865
of 10,614 outputs
Outputs of similar age
#43,303
of 160,638 outputs
Outputs of similar age from BMC Genomics
#18
of 57 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 10,614 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,638 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.