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Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

Overview of attention for article published in BMC Genomics, March 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Readers on

mendeley
50 Mendeley
citeulike
2 CiteULike
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Title
Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria
Published in
BMC Genomics, March 2012
DOI 10.1186/1471-2164-13-106
Pubmed ID
Authors

Katarzyna Kinga Modrzynska, Alison Creasey, Laurence Loewe, Timothee Cezard, Sofia Trindade Borges, Axel Martinelli, Louise Rodrigues, Pedro Cravo, Mark Blaxter, Richard Carter, Paul Hunt

Abstract

Drug resistance in the malaria parasite Plasmodium falciparum severely compromises the treatment and control of malaria. A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of drug action and mechanisms of resistances. They are required to design better therapies and limit drug resistance.A mutation in the gene (pfcrt) encoding a membrane transporter has been identified as a principal determinant of chloroquine resistance in P. falciparum, but we lack a full account of higher level chloroquine resistance. Furthermore, the determinants of resistance in the other major human malaria parasite, P. vivax, are not known. To address these questions, we investigated the genetic basis of chloroquine resistance in an isogenic lineage of rodent malaria parasite P. chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
United States 2 4%
Indonesia 1 2%
India 1 2%
Unknown 44 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 26%
Researcher 10 20%
Other 5 10%
Student > Master 4 8%
Student > Bachelor 3 6%
Other 10 20%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 42%
Biochemistry, Genetics and Molecular Biology 8 16%
Medicine and Dentistry 6 12%
Immunology and Microbiology 3 6%
Chemistry 3 6%
Other 2 4%
Unknown 7 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2018.
All research outputs
#4,024,938
of 14,884,620 outputs
Outputs from BMC Genomics
#2,192
of 8,578 outputs
Outputs of similar age
#31,381
of 124,198 outputs
Outputs of similar age from BMC Genomics
#1
of 2 outputs
Altmetric has tracked 14,884,620 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 8,578 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,198 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them