Title |
Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation
|
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Published in |
Journal of Neuroinflammation, May 2010
|
DOI | 10.1186/1742-2094-7-30 |
Pubmed ID | |
Authors |
Henrik Wilms, Jobst Sievers, Uta Rickert, Martin Rostami-Yazdi, Ulrich Mrowietz, Ralph Lucius |
Abstract |
Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the effector cells of neuroinflammation; however, little is known of the effect of DMF on microglia and astrocytes. The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Serbia | 2 | <1% |
Mexico | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 200 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 46 | 22% |
Researcher | 35 | 17% |
Student > Bachelor | 21 | 10% |
Student > Master | 18 | 9% |
Student > Doctoral Student | 15 | 7% |
Other | 39 | 19% |
Unknown | 32 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 56 | 27% |
Medicine and Dentistry | 30 | 15% |
Neuroscience | 25 | 12% |
Biochemistry, Genetics and Molecular Biology | 15 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
Other | 26 | 13% |
Unknown | 42 | 20% |