Title |
Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim
|
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Published in |
Breast Cancer Research, March 2012
|
DOI | 10.1186/bcr3153 |
Pubmed ID | |
Authors |
Sudharsan Periyasamy-Thandavan, Suchreet Takhar, Adam Singer, Michael Robert Dohn, William Hutch Jackson, April Eve Welborn, Derek LeRoith, Mario Marrero, Muthusamy Thangaraju, Shuang Huang, Patricia Veronica Schoenlein |
Abstract |
In this pre-clinical in vitro study conducted in estrogen receptor positive (ER+) breast cancer cells, we have characterized the effects of insulin-like growth factor I (IGF-1) on the cytostatic and cytotoxic action of antiestrogen treatment when used as a single agent or in combination with the antiprogestin mifepristone (MIF). Our goal was to identify new molecular targets to improve the efficacy of hormonal therapy in breast cancer patients that have a poor response to hormonal therapy, in part, due to high circulating levels of unbound insulinIGF-1. |
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