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Association of infertility and fertility treatment with mammographic density in a large screening-based cohort of women: a cross-sectional study

Overview of attention for article published in Breast Cancer Research, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#22 of 2,053)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

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17 news outlets
blogs
3 blogs
twitter
7 X users
facebook
4 Facebook pages

Citations

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12 Dimensions

Readers on

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42 Mendeley
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Title
Association of infertility and fertility treatment with mammographic density in a large screening-based cohort of women: a cross-sectional study
Published in
Breast Cancer Research, April 2016
DOI 10.1186/s13058-016-0693-5
Pubmed ID
Authors

Frida E. Lundberg, Anna L. V. Johansson, Kenny Rodriguez-Wallberg, Judith S. Brand, Kamila Czene, Per Hall, Anastasia N. Iliadou

Abstract

Ovarian stimulation drugs, in particular hormonal agents used for controlled ovarian stimulation (COS) required to perform in vitro fertilization, increase estrogen and progesterone levels and have therefore been suspected to influence breast cancer risk. This study aims to investigate whether infertility and hormonal fertility treatment influences mammographic density, a strong hormone-responsive risk factor for breast cancer. Cross-sectional study including 43,313 women recruited to the Karolinska Mammography Project between 2010 and 2013. Among women who reported having had infertility, 1576 had gone through COS, 1429 had had hormonal stimulation without COS and 5958 had not received any hormonal fertility treatment. Percent and absolute mammographic densities were obtained using the volumetric method Volpara™. Associations with mammographic density were assessed using multivariable generalized linear models, estimating mean differences (MD) with 95 % confidence intervals (CI). After multivariable adjustment, women with a history of infertility had 1.53 cm(3) higher absolute dense volume compared to non-infertile women (95 % CI: 0.70 to 2.35). Among infertile women, only those who had gone through COS treatment had a higher absolute dense volume than those who had not received any hormone treatment (adjusted MD 3.22, 95 % CI: 1.10 to 5.33). No clear associations were observed between infertility, fertility treatment and percent volumetric density. Overall, women reporting infertility had more dense tissue in the breast. The higher absolute dense volume in women treated with COS may indicate a treatment effect, although part of the association might also be due to the underlying infertility. Continued monitoring of cancer risk in infertile women, especially those who undergo COS, is warranted.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 14%
Student > Bachelor 5 12%
Student > Master 4 10%
Researcher 4 10%
Student > Doctoral Student 2 5%
Other 6 14%
Unknown 15 36%
Readers by discipline Count As %
Medicine and Dentistry 14 33%
Agricultural and Biological Sciences 5 12%
Nursing and Health Professions 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Chemical Engineering 1 2%
Other 2 5%
Unknown 16 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 153. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2024.
All research outputs
#268,619
of 25,374,917 outputs
Outputs from Breast Cancer Research
#22
of 2,053 outputs
Outputs of similar age
#4,951
of 315,832 outputs
Outputs of similar age from Breast Cancer Research
#2
of 32 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.