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A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study

Overview of attention for article published in Breast Cancer Research, January 2012
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2 tweeters

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Title
A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
Published in
Breast Cancer Research, January 2012
DOI 10.1186/bcr3158
Pubmed ID
Authors

Kim, Hyung-cheol, Lee, Ji-Young, Sung, Hyuna, Choi, Ji-Yeob, Park, Sue K, Lee, Kyoung-Mu, Kim, Young Jin, Go, Min Jin, Li, Lian, Cho, Yoon Shin, Park, Miey, Kim, Dong-Joon, Oh, Ji Hee, Kim, Jun-Woo, Jeon, Jae-Pil, Jeon, Soon-Young, Min, Haesook, Kim, Hyo Mi, Park, Jaekyung, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Lee, Min Hyuk, Kim, Sung-Won, Lee, Jong Won, Park, Byeong-Woo, Park, Woong-Yang, Kim, Eun-Hye, Kim, Mi Kyung, Han, Wonshik, Lee, Sang-Ah, Matsuo, Keitaro, Shen, Chen-Yang, Wu, Pei-Ei, Hsiung, Chia-Ni, Lee, Jong-Young, Kim, Hyung-Lae, Han, Bok-Ghee, Kang, Daehee

Abstract

Although approximately 25 common genetic susceptibility loci have been identified to be independently associated with breast cancer risk through genome-wide association studies (GWAS), the genetic risk variants reported to date only explain a small fraction of the heritability of breast cancer. Furthermore, GWAS-identified loci were primarily identified in women of European descent. To evaluate previously identified loci in Korean women and to identify additional novel breast cancer susceptibility variants, we conducted a three-stage GWAS that included 6,322 cases and 5,897 controls. In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05). To identify additional genetic risk variants, we selected the most promising 17 SNPs in Stage I and replicated these SNPs in 2,052 cases and 2,169 controls (Stage II). Four SNPs were further evaluated in 1,997 cases and 1,676 controls (Stage III). SNP rs13393577 at chromosome 2q34, located in the Epidermal Growth Factor Receptor 4 (ERBB4) gene, showed a consistent association with breast cancer risk with combined odds ratios (95% CI) of 1.53 (1.37-1.70) (combined P for trend = 8.8 × 10-14). This study shows that seven breast cancer susceptibility loci, which were previously identified in European and/or Chinese populations, could be directly replicated in Korean women. Furthermore, this study provides strong evidence implicating rs13393577 at 2q34 as a new risk variant for breast cancer.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
China 1 2%
Unknown 53 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 22%
Researcher 9 16%
Student > Master 8 15%
Student > Bachelor 7 13%
Professor > Associate Professor 4 7%
Other 9 16%
Unknown 6 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 27%
Biochemistry, Genetics and Molecular Biology 12 22%
Medicine and Dentistry 12 22%
Computer Science 3 5%
Chemistry 2 4%
Other 4 7%
Unknown 7 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2012.
All research outputs
#9,533,391
of 14,976,421 outputs
Outputs from Breast Cancer Research
#1,156
of 1,608 outputs
Outputs of similar age
#72,405
of 125,038 outputs
Outputs of similar age from Breast Cancer Research
#25
of 36 outputs
Altmetric has tracked 14,976,421 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,608 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.