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MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin

Overview of attention for article published in Cancer Cell International, April 2016
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3 X users

Citations

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27 Mendeley
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Title
MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin
Published in
Cancer Cell International, April 2016
DOI 10.1186/s12935-016-0305-6
Pubmed ID
Authors

Weili Li, Wenzhe Wang, Mingjian Ding, Xiaoliang Zheng, Shenglin Ma, Xiaoju Wang

Abstract

Cisplatin (DDP)-based chemotherapy is the mainstay of first-line therapy for lung cancer. However, their efficacy is often limited by the existence or development of chemoresistance. The aim of this study was to find and investigate the function of miRNAs in cisplatin (DDP)-resistant non-small cell lung cancer (NSCLC) A549 cell. Quantitative real-time PCR assay was employed to compare the differences of miRNA expression in both cisplatin-resistant A549 (A549/DDP) cell and the parental A549 cell. The dysregulated miRNAs were then corrected by transfecting oligonucleotides into A549/DDP cells. The cellular sensitivity to cisplatin, cell apoptosis and migration were conducted by MTT, flow cytometry and cell wound healing assay, respectively. Both miR-589 and miR-1244 were significantly down-regulated in A549/DDP cell compared to the parental A549, while the expression of miR-182 and miR-224 were increased in A549/DDP cell (P < 0.05). Importantly, transfection of the cisplatin-resistant cells with either miR-589 or miR-1244 resulted in an increased sensitivity to cisplatin, indicating that the dysregulated miRNA may play an important role in chemotherapy resistance in cancer cell. The rescued expression of miRNA also reduced cell invasion and increased apoptosis of A549/DDP cell. The study indicates a crucial role of miR-1244 in the progress of cisplatin resistance of A549. Further understanding of miR-1244-mediated signaling pathways may promote the clinical use of miR-1244 in lung cancer therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 15%
Student > Doctoral Student 3 11%
Student > Ph. D. Student 3 11%
Other 2 7%
Student > Bachelor 2 7%
Other 6 22%
Unknown 7 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 26%
Agricultural and Biological Sciences 5 19%
Medicine and Dentistry 3 11%
Unspecified 1 4%
Arts and Humanities 1 4%
Other 3 11%
Unknown 7 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2016.
All research outputs
#15,174,308
of 23,339,727 outputs
Outputs from Cancer Cell International
#805
of 1,849 outputs
Outputs of similar age
#172,692
of 302,108 outputs
Outputs of similar age from Cancer Cell International
#4
of 16 outputs
Altmetric has tracked 23,339,727 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,849 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,108 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.