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Comparative study of serum proteomes in Legg-Calve-Perthes disease

Overview of attention for article published in BMC Musculoskeletal Disorders, October 2015
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Title
Comparative study of serum proteomes in Legg-Calve-Perthes disease
Published in
BMC Musculoskeletal Disorders, October 2015
DOI 10.1186/s12891-015-0730-z
Pubmed ID
Authors

Ruiyu Liu, Lihong Fan, Longbin Yin, Kunzheng Wang, Wusheng Miao, Qichun Song, Xiaoqian Dang, Hang Gao, Chuanyi Bai

Abstract

Legg-Calve-Perthes Disease (LCPD) is an idiopathic osteonecrosis of the developing femoral head complicated by pain and disability of the hip joint. To date, the pathological mechanisms of LCPD are not well-known. This study screened the changes in serum protein expression in patients with LCPD. Age- and sex-matched serum samples from 10 control subjects and 10 patients with LCPD were compared using the isobaric tags for relative and absolute quantification (iTRAQ) technique. Gene ontology analyses, KEGG pathway and functional network analyses were performed. Proteins of interest with large differences in expression, S100-A8, alpha-1-acid glycoprotein 1, haptoglobin and apolipoprotein E, were compared by western blotting. The disease/control ratios showed 26 proteins were significantly differentially expressed (all p < 0.05). Including higher abundances of complement factor H (1.44), complement C4-B (1.45), isocitrate dehydrogenase [NAD] subunit alpha (2.7) alpha-1-acid glycoprotein 1 (1.87), heptoglobin (1.53) and Ig lambda-2 chain C regions (1.46), and lower levels of apolipoprotein E (0.50), apolipoprotein F (0.60), apolipoprotein C-III (0.69), S100-A8 (0.73), S100-A9 (0.75) and prothrombin (0.77) in LCPD than in controls. The alpha-1-acid glycoprotein 1 and haptoglobin increases, and apolipoprotein E and S100-A8 decreases were confirmed by western blot. KEGG pathway analysis revealed these proteins were related to the complement and coagulation cascades, Staphylococcus aureus infection, PPAR signaling, fat digestion and absorption, and vitamin digestion and absorption. Functional network analysis suggested that the proteins were involved in lipid regulation. The complement and coagulation cascades, and abnormal lipid metabolism may be involved in the pathogenesis of LCPD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 13%
Student > Doctoral Student 5 13%
Unspecified 4 11%
Student > Postgraduate 4 11%
Researcher 3 8%
Other 6 16%
Unknown 11 29%
Readers by discipline Count As %
Medicine and Dentistry 11 29%
Veterinary Science and Veterinary Medicine 4 11%
Unspecified 4 11%
Neuroscience 2 5%
Nursing and Health Professions 1 3%
Other 2 5%
Unknown 14 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2016.
All research outputs
#17,274,982
of 25,371,292 outputs
Outputs from BMC Musculoskeletal Disorders
#2,669
of 4,396 outputs
Outputs of similar age
#170,481
of 284,633 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#55
of 83 outputs
Altmetric has tracked 25,371,292 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,396 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,633 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.