Title |
Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth
|
---|---|
Published in |
Journal of Ovarian Research, April 2010
|
DOI | 10.1186/1757-2215-3-11 |
Pubmed ID | |
Authors |
Murali M Yallapu, Diane M Maher, Vasudha Sundram, Maria C Bell, Meena Jaggi, Subhash C Chauhan |
Abstract |
Chemo/radio-resistance is a major obstacle in treating advanced ovarian cancer. The efficacy of current treatments may be improved by increasing the sensitivity of cancer cells to chemo/radiation therapies. Curcumin is a naturally occurring compound with anti-cancer activity in multiple cancers; however, its chemo/radio-sensitizing potential is not well studied in ovarian cancer. Herein, we demonstrate the effectiveness of a curcumin pre-treatment strategy for chemo/radio-sensitizing cisplatin resistant ovarian cancer cells. To improve the efficacy and specificity of curcumin induced chemo/radio sensitization, we developed a curcumin nanoparticle formulation conjugated with a monoclonal antibody specific for cancer cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Egypt | 2 | <1% |
India | 2 | <1% |
Vietnam | 1 | <1% |
Malaysia | 1 | <1% |
Italy | 1 | <1% |
Australia | 1 | <1% |
Unknown | 213 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 48 | 22% |
Student > Master | 29 | 13% |
Student > Bachelor | 25 | 11% |
Researcher | 24 | 11% |
Student > Doctoral Student | 14 | 6% |
Other | 42 | 19% |
Unknown | 39 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 22% |
Medicine and Dentistry | 38 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 25 | 11% |
Biochemistry, Genetics and Molecular Biology | 19 | 9% |
Chemistry | 16 | 7% |
Other | 25 | 11% |
Unknown | 50 | 23% |