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Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases

Overview of attention for article published in Malaria Journal, April 2016
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Title
Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases
Published in
Malaria Journal, April 2016
DOI 10.1186/s12936-016-1247-0
Pubmed ID
Authors

Sameena Khan

Abstract

Escalating drug resistance in malaria parasites and lack of vaccine entails the discovery of novel drug targets and inhibitor molecules. The multi-component protein translation machinery is a rich source of such drug targets. Malaria parasites contain three translational compartments: the cytoplasm, apicoplast and mitochondrion, of which the latter two are of the prokaryotic type. Recent explorations by many groups into the malaria parasite protein translation enzymes, aminoacyl-tRNA synthetases (aaRSs), have yielded many promising inhibitors. The understanding of the biology of this unique set of 36 enzymes has become much clearer in recent times. Current review discusses the advances made in understanding of crucial aaRSs from Plasmodium and also the specific inhibitors found against malaria aaRSs.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 80 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 21%
Student > Bachelor 11 14%
Student > Master 11 14%
Researcher 7 9%
Other 5 6%
Other 8 10%
Unknown 22 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 22%
Pharmacology, Toxicology and Pharmaceutical Science 10 12%
Agricultural and Biological Sciences 8 10%
Chemistry 8 10%
Medicine and Dentistry 5 6%
Other 8 10%
Unknown 24 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2016.
All research outputs
#16,727,891
of 24,601,689 outputs
Outputs from Malaria Journal
#4,554
of 5,762 outputs
Outputs of similar age
#186,558
of 306,292 outputs
Outputs of similar age from Malaria Journal
#143
of 175 outputs
Altmetric has tracked 24,601,689 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,762 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,292 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 175 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.