Title |
Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases
|
---|---|
Published in |
Malaria Journal, April 2016
|
DOI | 10.1186/s12936-016-1247-0 |
Pubmed ID | |
Authors |
Sameena Khan |
Abstract |
Escalating drug resistance in malaria parasites and lack of vaccine entails the discovery of novel drug targets and inhibitor molecules. The multi-component protein translation machinery is a rich source of such drug targets. Malaria parasites contain three translational compartments: the cytoplasm, apicoplast and mitochondrion, of which the latter two are of the prokaryotic type. Recent explorations by many groups into the malaria parasite protein translation enzymes, aminoacyl-tRNA synthetases (aaRSs), have yielded many promising inhibitors. The understanding of the biology of this unique set of 36 enzymes has become much clearer in recent times. Current review discusses the advances made in understanding of crucial aaRSs from Plasmodium and also the specific inhibitors found against malaria aaRSs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 21% |
Student > Bachelor | 11 | 14% |
Student > Master | 11 | 14% |
Researcher | 7 | 9% |
Other | 5 | 6% |
Other | 8 | 10% |
Unknown | 22 | 27% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 18 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 12% |
Agricultural and Biological Sciences | 8 | 10% |
Chemistry | 8 | 10% |
Medicine and Dentistry | 5 | 6% |
Other | 8 | 10% |
Unknown | 24 | 30% |