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l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia

Overview of attention for article published in Journal of Hematology & Oncology, April 2016
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Mentioned by

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2 tweeters

Citations

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28 Dimensions

Readers on

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19 Mendeley
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Title
l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia
Published in
Journal of Hematology & Oncology, April 2016
DOI 10.1186/s13045-016-0271-4
Pubmed ID
Authors

Ki Sun Jung, Su-Hee Cho, Seok Jin Kim, Young Hyeh Ko, Eun-Suk Kang, Won Seog Kim

Abstract

Aggressive nature killer cell leukemia (ANKL) is a mature NK-T cell lymphoma with worse prognosis, but optimal treatment is unclear. Therefore, we analyzed the efficacy of L-asparaginase-based regimens for ANKL patients. Twenty-one patients who received dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) or etoposide, ifosfamide, dexamethasone, and L-asparaginase (VIDL) chemotherapy at Samsung Medical Center were selected. The overall response rate for all patients was 33 % (7/21); 38 % (5/13) in SMILE and 40 % (2/5) in VIDL, respectively. The median progression-free survival was 3.9 months (95 % CI 0.0-8.1 months) and median overall survival was 7.0 months (95 % CI 2.3-11.7 months). Treatment response (P = 0.001), hematopoietic stem cell transplantation (HSCT) (P = 0.007) and negative conversion of Epstein-Barr virus (EBV) DNA titer after treatment (P = 0.004) were significantly associated with survival. Thus, L-asparaginase-based regimens followed by allogeneic HSCT seem to improve the outcome for ANKL patients.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 21%
Professor > Associate Professor 3 16%
Student > Ph. D. Student 3 16%
Student > Master 3 16%
Other 1 5%
Other 1 5%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 8 42%
Biochemistry, Genetics and Molecular Biology 4 21%
Agricultural and Biological Sciences 1 5%
Neuroscience 1 5%
Engineering 1 5%
Other 0 0%
Unknown 4 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2016.
All research outputs
#3,697,158
of 7,578,098 outputs
Outputs from Journal of Hematology & Oncology
#125
of 322 outputs
Outputs of similar age
#133,185
of 267,247 outputs
Outputs of similar age from Journal of Hematology & Oncology
#5
of 23 outputs
Altmetric has tracked 7,578,098 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 322 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,247 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.