Title |
l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia
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Published in |
Journal of Hematology & Oncology, April 2016
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DOI | 10.1186/s13045-016-0271-4 |
Pubmed ID | |
Authors |
Ki Sun Jung, Su-Hee Cho, Seok Jin Kim, Young Hyeh Ko, Eun-Suk Kang, Won Seog Kim |
Abstract |
Aggressive nature killer cell leukemia (ANKL) is a mature NK-T cell lymphoma with worse prognosis, but optimal treatment is unclear. Therefore, we analyzed the efficacy of L-asparaginase-based regimens for ANKL patients. Twenty-one patients who received dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) or etoposide, ifosfamide, dexamethasone, and L-asparaginase (VIDL) chemotherapy at Samsung Medical Center were selected. The overall response rate for all patients was 33 % (7/21); 38 % (5/13) in SMILE and 40 % (2/5) in VIDL, respectively. The median progression-free survival was 3.9 months (95 % CI 0.0-8.1 months) and median overall survival was 7.0 months (95 % CI 2.3-11.7 months). Treatment response (P = 0.001), hematopoietic stem cell transplantation (HSCT) (P = 0.007) and negative conversion of Epstein-Barr virus (EBV) DNA titer after treatment (P = 0.004) were significantly associated with survival. Thus, L-asparaginase-based regimens followed by allogeneic HSCT seem to improve the outcome for ANKL patients. |
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Members of the public | 2 | 100% |
Mendeley readers
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Unknown | 20 | 100% |
Demographic breakdown
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Researcher | 4 | 20% |
Professor > Associate Professor | 3 | 15% |
Student > Master | 3 | 15% |
Student > Ph. D. Student | 3 | 15% |
Other | 1 | 5% |
Other | 2 | 10% |
Unknown | 4 | 20% |
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Biochemistry, Genetics and Molecular Biology | 4 | 20% |
Agricultural and Biological Sciences | 1 | 5% |
Neuroscience | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 20% |