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High-resolution intravascular magnetic resonance quantification of atherosclerotic plaque at 3T

Overview of attention for article published in Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd), March 2012
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  • Good Attention Score compared to outputs of the same age (73rd percentile)

Mentioned by

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2 tweeters
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1 patent

Citations

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17 Dimensions

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21 Mendeley
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Title
High-resolution intravascular magnetic resonance quantification of atherosclerotic plaque at 3T
Published in
Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd), March 2012
DOI 10.1186/1532-429x-14-20
Pubmed ID
Authors

Di Qian, Paul A Bottomley

Abstract

The thickness of fibrous caps (FCT) of atherosclerotic lesions is a critical factor affecting plaque vulnerability to rupture. This study tests whether 3 Tesla high-resolution intravascular cardiovascular magnetic resonance (CMR) employing tiny loopless detectors can identify lesions and accurately measure FCT in human arterial specimens, and whether such an approach is feasible in vivo using animal models. Receive-only 2.2 mm and 0.8 mm diameter intravascular loopless CMR detectors were fabricated for a clinical 3 Tesla MR scanner, and the absolute signal-to-noise ratio determined. The detectors were applied in a two-step protocol comprised of CMR angiography to identify atherosclerotic lesions, followed by high-resolution CMR to characterize FCT, lesion size, and/or vessel wall thickness. The protocol was applied in fresh human iliac and carotid artery specimens in a human-equivalent saline bath. Mean FCT measured by 80 μm intravascular CMR was compared with histology of the same sections. In vivo studies compared aortic wall thickness and plaque size in healthy and hyperlipidemic rabbit models, with post-mortem histology. Histology confirmed plaques in human specimens, with calcifications appearing as signal voids. Mean FCT agreed with histological measurements within 13% on average (correlation coefficient, R = 0.98; Bland-Altman analysis, -1.3 ± 68.9 μm). In vivo aortic wall and plaque size measured by 80 μm intravascular CMR agreed with histology. Intravascular 3T CMR with loopless detectors can both locate atherosclerotic lesions, and accurately measure FCT at high-resolution in a strategy that appears feasible in vivo. The approach shows promise for quantifying vulnerable plaque for evaluating experimental therapies.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Switzerland 1 5%
Unknown 19 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 29%
Student > Master 3 14%
Student > Ph. D. Student 3 14%
Professor > Associate Professor 2 10%
Professor 2 10%
Other 3 14%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 10 48%
Engineering 4 19%
Physics and Astronomy 1 5%
Nursing and Health Professions 1 5%
Neuroscience 1 5%
Other 1 5%
Unknown 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2019.
All research outputs
#4,093,569
of 15,071,208 outputs
Outputs from Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd)
#405
of 956 outputs
Outputs of similar age
#31,913
of 125,267 outputs
Outputs of similar age from Journal of Cardiovascular Magnetic Resonance (Taylor & Francis Ltd)
#1
of 1 outputs
Altmetric has tracked 15,071,208 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 956 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,267 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them