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Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK

Overview of attention for article published in Journal of Neuroinflammation, April 2016
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Title
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK
Published in
Journal of Neuroinflammation, April 2016
DOI 10.1186/s12974-016-0550-6
Pubmed ID
Authors

Yan-jing Yang, Liang Hu, Ye-peng Xia, Chun-yi Jiang, Chen Miao, Chun-qing Yang, Miao Yuan, Lin Wang

Abstract

Glial activation and neuroinflammation in the spinal trigeminal nucleus (STN) play a pivotal role in the genesis and maintenance of trigeminal neuralgia (TN). Resveratrol, a natural compound from grape and red wine, has a potential anti-inflammatory effect. We hypothesized that resveratrol could significantly suppress neuroinflammation in the STN mediated by glial activation and further relieve TN. In this study, we evaluated whether resveratrol could alleviate trigeminal allodynia and explore the mechanism underlying the antinociceptive effect of resveratrol. Animals were orally injected with resveratrol after chronic constriction injury (CCI) of the infraorbital nerve. Mechanical thresholds of the affected whisker pad were measured to assess nociceptive behaviors. The STN was harvested to quantify the changing levels of p-NR1, p-PKC, TNF-α, and IL1-β by western blotting and detect the expression of calcitonin gene-related peptide (CGRP) and c-Fos by immunofluorescence. Glial activation was observed by immunofluorescence and western blotting. Mitogen-activated protein kinase (MAPK) phosphorylation in vivo and in vitro was examined by western blotting. We found that resveratrol significantly attenuated trigeminal allodynia dose-dependently and decreased the increased expression of CGRP and c-Fos in the STN. Additionally, resveratrol showed an inhibitory effect on CCI-evoked astrocyte and microglia activation and reduced production of pro-inflammatory cytokines in the STN. Furthermore, the antinociceptive effect of resveratrol was partially mediated by reduced phosphorylation of MAP kinases via adenosine monophosphate-activated protein kinase (AMPK) activation. AMPK activation in the STN glia via resveratrol has utility in the treatment of CCI-induced neuroinflammation and further implicates AMPK as a novel target for the attenuation of trigeminal neuralgia.

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Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 19%
Researcher 6 12%
Student > Postgraduate 6 12%
Student > Ph. D. Student 6 12%
Professor 3 6%
Other 13 25%
Unknown 8 15%
Readers by discipline Count As %
Medicine and Dentistry 12 23%
Biochemistry, Genetics and Molecular Biology 7 13%
Agricultural and Biological Sciences 7 13%
Neuroscience 6 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Other 2 4%
Unknown 14 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2016.
All research outputs
#5,742,096
of 7,588,328 outputs
Outputs from Journal of Neuroinflammation
#706
of 981 outputs
Outputs of similar age
#186,949
of 267,080 outputs
Outputs of similar age from Journal of Neuroinflammation
#48
of 60 outputs
Altmetric has tracked 7,588,328 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 981 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.