Title |
Should we use cells, biomaterials, or tissue engineering for cartilage regeneration?
|
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Published in |
Stem Cell Research & Therapy, April 2016
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DOI | 10.1186/s13287-016-0314-3 |
Pubmed ID | |
Authors |
Jonathan C. Bernhard, Gordana Vunjak-Novakovic |
Abstract |
For a long time, cartilage has been a major focus of the whole field of tissue engineering, both because of the constantly growing need for more effective options for joint repair and the expectation that this apparently simple tissue will be easy to engineer. After several decades, cartilage regeneration has proven to be anything but easy. With gratifying progress in our understanding of the factors governing cartilage development and function, and cell therapy being successfully used for several decades, there is still a lot to do. We lack reliable methods to generate durable articular cartilage that would resemble the original tissue lost to injury or disease. The question posed here is whether the answer would come from the methods using cells, biomaterials, or tissue engineering. We present a concise review of some of the most meritorious efforts in each area, and propose that the solution will most likely emerge from the ongoing attempts to recapitulate certain aspects of native cartilage development. While an ideal recipe for cartilage regeneration is yet to be formulated, we believe that it will contain cell, biomaterial, and tissue engineering approaches, blended into an effective method for seamless repair of articular cartilage. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 13% |
United States | 2 | 13% |
Saudi Arabia | 1 | 6% |
Colombia | 1 | 6% |
Curaçao | 1 | 6% |
Ireland | 1 | 6% |
Netherlands | 1 | 6% |
Turkey | 1 | 6% |
Switzerland | 1 | 6% |
Other | 0 | 0% |
Unknown | 5 | 31% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 12 | 75% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Scientists | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Switzerland | 1 | <1% |
Unknown | 278 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 61 | 22% |
Student > Master | 44 | 16% |
Student > Bachelor | 40 | 14% |
Researcher | 25 | 9% |
Student > Doctoral Student | 15 | 5% |
Other | 35 | 12% |
Unknown | 62 | 22% |
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---|---|---|
Engineering | 46 | 16% |
Biochemistry, Genetics and Molecular Biology | 42 | 15% |
Medicine and Dentistry | 35 | 12% |
Agricultural and Biological Sciences | 25 | 9% |
Materials Science | 20 | 7% |
Other | 37 | 13% |
Unknown | 77 | 27% |