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Effectiveness of blended depression treatment for adults in specialised mental healthcare: study protocol for a randomised controlled trial

Overview of attention for article published in BMC Psychiatry, April 2016
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1 tweeter
1 Facebook page


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263 Mendeley
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Effectiveness of blended depression treatment for adults in specialised mental healthcare: study protocol for a randomised controlled trial
Published in
BMC Psychiatry, April 2016
DOI 10.1186/s12888-016-0818-5
Pubmed ID

L. L. Kemmeren, D. J. F. van Schaik, H. Riper, A. M. Kleiboer, J. E. Bosmans, J. H. Smit


Internet-based interventions are seen as an important potential strategy to improve accessibility and affordability of high quality treatments in mental healthcare. A growing number of studies have demonstrated the clinical efficacy of internet-based treatment for mood disorders, but scientific evidence for the application in routine specialised mental healthcare settings is limited. Also, little is known about the clinical and health-economic benefits of blended treatment, where online interventions are integrated with face-to-face treatment of depression in one treatment protocol. The primary aim of this study is to investigate the clinical and cost-effectiveness of blended Cognitive Behavioural Therapy (bCBT) for depression, as compared to treatment as usual (TAU) in specialised routine mental healthcare in the Netherlands. This trial is part of the E-COMPARED project which has a broader perspective, focussing on primary and specialised care in eight European countries. The study is a randomised controlled non-inferiority trial with two parallel conditions: bCBT and TAU. The blended treatment combines individual face-to-face CBT with CBT delivered through an Internet-based treatment platform (Moodbuster). This platform includes a mobile phone application, used for ecological momentary assessments, automated feedback and motivational messages. Weekly alternating face-to-face (10) and online (9) sessions will be delivered over a period of 19-20 weeks. TAU is defined as the routine care that subjects receive when they are diagnosed with depression in specialised mental healthcare. Adult patients ≥ 18 years old meeting DSM-IV diagnostic criteria for major depressive disorder will be recruited within participating outpatient specialised mental healthcare clinics in the Netherlands. Measurements will be taken at baseline and at 3, 6 and 12 months follow-up. The primary outcome will be depressive symptoms, measured with the PHQ-9 and QIDS. Secondary outcomes include health-related quality of life, mastery, treatment preference, working alliance, system usability, treatment satisfaction and possible negative side-effects. Moreover, a cost-effectiveness analysis will be conducted from a societal perspective and will include both direct and indirect healthcare costs. The results of this study will provide insight into the health and economical outcomes of blended treatment for depression and give an indication of the value of implementing blended treatment in specialised clinical settings. Netherlands Trial Register NTR4962 . Registered 05-01-2015.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 263 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
Brazil 1 <1%
Sweden 1 <1%
South Africa 1 <1%
United Kingdom 1 <1%
Unknown 258 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 49 19%
Student > Ph. D. Student 43 16%
Researcher 32 12%
Student > Bachelor 31 12%
Student > Doctoral Student 13 5%
Other 42 16%
Unknown 53 20%
Readers by discipline Count As %
Psychology 102 39%
Medicine and Dentistry 32 12%
Social Sciences 15 6%
Computer Science 11 4%
Nursing and Health Professions 11 4%
Other 32 12%
Unknown 60 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2016.
All research outputs
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Outputs from BMC Psychiatry
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Outputs of similar age
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Outputs of similar age from BMC Psychiatry
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Altmetric has tracked 14,533,317 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,293 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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