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Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice

Overview of attention for article published in BMC Plant Biology, April 2012
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1 X user
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Citations

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10 Dimensions

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48 Mendeley
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1 CiteULike
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Title
Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice
Published in
BMC Plant Biology, April 2012
DOI 10.1186/1471-2229-12-48
Pubmed ID
Authors

Xuejiao Yang, Yingjie Yu, Lily Jiang, Xiuyun Lin, Chunyu Zhang, Xiufang Ou, Kenji Osabe, Bao Liu

Abstract

Etoposide (epipodophyllotoxin) is a chemical commonly used as an anti-cancer drug which inhibits DNA synthesis by blocking topoisomerase II activity. Previous studies in animal cells have demonstrated that etoposide constitutes a genotoxic stress which may induce genomic instability including mobilization of normally quiescent transposable elements (TEs). However, it remained unknown whether similar genetically mutagenic effects could be imposed by etoposide in plant cells. Also, no information is available with regard to whether the drug may cause a perturbation of epigenetic stability in any organism.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
New Zealand 1 2%
France 1 2%
Brazil 1 2%
Unknown 44 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 33%
Student > Ph. D. Student 11 23%
Professor 5 10%
Professor > Associate Professor 4 8%
Lecturer > Senior Lecturer 2 4%
Other 5 10%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 73%
Biochemistry, Genetics and Molecular Biology 6 13%
Nursing and Health Professions 1 2%
Arts and Humanities 1 2%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2012.
All research outputs
#17,656,152
of 22,664,267 outputs
Outputs from BMC Plant Biology
#1,853
of 3,207 outputs
Outputs of similar age
#120,250
of 161,201 outputs
Outputs of similar age from BMC Plant Biology
#10
of 16 outputs
Altmetric has tracked 22,664,267 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,207 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,201 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.