Title |
A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States
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Published in |
Clinical Epigenetics, April 2012
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DOI | 10.1186/1868-7083-4-6 |
Pubmed ID | |
Authors |
Renee Dufault, Walter J Lukiw, Raquel Crider, Roseanne Schnoll, David Wallinga, Richard Deth |
Abstract |
The number of children ages 6 to 21 in the United States receiving special education services under the autism disability category increased 91% between 2005 to 2010 while the number of children receiving special education services overall declined by 5%. The demand for special education services continues to rise in disability categories associated with pervasive developmental disorders. Neurodevelopment can be adversely impacted when gene expression is altered by dietary transcription factors, such as zinc insufficiency or deficiency, or by exposure to toxic substances found in our environment, such as mercury or organophosphate pesticides. Gene expression patterns differ geographically between populations and within populations. Gene variants of paraoxonase-1 are associated with autism in North America, but not in Italy, indicating regional specificity in gene-environment interactions. In the current review, we utilize a novel macroepigenetic approach to compare variations in diet and toxic substance exposure between these two geographical populations to determine the likely factors responsible for the autism epidemic in the United States. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 14 | 28% |
Denmark | 2 | 4% |
Australia | 2 | 4% |
United Kingdom | 2 | 4% |
Canada | 2 | 4% |
Vietnam | 1 | 2% |
China | 1 | 2% |
Brazil | 1 | 2% |
Netherlands | 1 | 2% |
Other | 3 | 6% |
Unknown | 21 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 44 | 88% |
Scientists | 4 | 8% |
Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 4% |
Australia | 1 | <1% |
France | 1 | <1% |
Denmark | 1 | <1% |
Israel | 1 | <1% |
Unknown | 128 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 17% |
Student > Ph. D. Student | 22 | 16% |
Student > Master | 16 | 12% |
Other | 14 | 10% |
Student > Bachelor | 14 | 10% |
Other | 28 | 20% |
Unknown | 21 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 22% |
Agricultural and Biological Sciences | 22 | 16% |
Psychology | 13 | 9% |
Social Sciences | 8 | 6% |
Biochemistry, Genetics and Molecular Biology | 7 | 5% |
Other | 28 | 20% |
Unknown | 29 | 21% |