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Novel therapeutic strategies targeting HIV integrase

Overview of attention for article published in BMC Medicine, April 2012
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 X users
wikipedia
1 Wikipedia page

Citations

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67 Dimensions

Readers on

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95 Mendeley
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Title
Novel therapeutic strategies targeting HIV integrase
Published in
BMC Medicine, April 2012
DOI 10.1186/1741-7015-10-34
Pubmed ID
Authors

Peter K Quashie, Richard D Sloan, Mark A Wainberg

Abstract

Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted efforts, the first viable integrase inhibitors were developed in the early 2000s, ultimately leading to the clinical licensure of the first integrase strand transfer inhibitor, raltegravir. Similarly structured compounds and derivative second generation integrase strand transfer inhibitors, such as elvitegravir and dolutegravir, are now in various stages of clinical development. Furthermore, other mechanisms aimed at the inhibition of viral integration are being explored in numerous preclinical studies, which include inhibition of 3' processing and chromatin targeting. The development of new clinically useful compounds will be aided by the characterization of the retroviral intasome crystal structure. This review considers the history of the clinical development of HIV integrase inhibitors, the development of antiviral drug resistance and the need for new antiviral compounds.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
United Kingdom 2 2%
Portugal 2 2%
Netherlands 1 1%
Unknown 87 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 16%
Researcher 13 14%
Student > Bachelor 13 14%
Student > Master 12 13%
Other 8 8%
Other 18 19%
Unknown 16 17%
Readers by discipline Count As %
Medicine and Dentistry 28 29%
Agricultural and Biological Sciences 20 21%
Chemistry 11 12%
Biochemistry, Genetics and Molecular Biology 7 7%
Immunology and Microbiology 3 3%
Other 7 7%
Unknown 19 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2017.
All research outputs
#6,109,035
of 22,664,267 outputs
Outputs from BMC Medicine
#2,333
of 3,397 outputs
Outputs of similar age
#41,486
of 161,626 outputs
Outputs of similar age from BMC Medicine
#21
of 31 outputs
Altmetric has tracked 22,664,267 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,397 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,626 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.