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Insecticide resistance status of the Anopheles funestus population in Central African Republic: a challenge in the war

Overview of attention for article published in Parasites & Vectors, April 2016
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Mentioned by

twitter
3 tweeters

Citations

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20 Dimensions

Readers on

mendeley
80 Mendeley
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2 CiteULike
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Title
Insecticide resistance status of the Anopheles funestus population in Central African Republic: a challenge in the war
Published in
Parasites & Vectors, April 2016
DOI 10.1186/s13071-016-1510-9
Pubmed ID
Authors

Marina Lidwine Olé Sangba, Tanguy Deketramete, Solange Patricia Wango, Mirdad Kazanji, Martin Akogbeto, Mamadou Ousmane Ndiath

Abstract

In the Central African Republic, malaria is a major public health problem and the leading cause of death among children. This disease appears to be hyperendemic but no substantial entomological data, including data on Anopheles spp. susceptibility to insecticides, is available. This study evaluates, for the first time in the CAR, the status of insecticide resistance in the Anopheles funestus population, the second major vector of malaria in Africa. WHO standard bioassay susceptibility tests were performed on the An. funestus population using F1 generation from gravid females mosquitoes (F0) collected by manual aspirator sampling of households in Gbanikola, Bangui in October 2014 to assess: (i) An. funestus susceptibility to bendiocarb, malathion, permethrin, lamda-cyhalothrin, deltamethrin and DDT, and (ii) the effect of pre-exposure to the piperonyl butoxide (PBO) synergist on insecticide susceptibility. Additional tests were conducted to investigate metabolic resistance status (cytochrome P450 monooxygenases, glutathione S-transferases, and esterases). A high phenotypic resistance of An. funestus population to malathion, DDT and pyrethroids was observed with a mortality rate ranging from 23 to 74 %. For the pyrethroid groups, the mortality rate was 35, 31 and 23 % for lambda-cyhalothrin, deltamethrin, and permethrin, respectively. In contrast a 100 % mortality rate to bendiocarb was recorded. Knockdown time (KDT) was long for all pyrethroids, DDT and malathion with KDT50 higher than 50 min. Pre-exposure of An. funestus to PBO synergist significantly restored susceptibility to all pyrethroids (Fisher's exact test P <0.0001) but not in DDT (Fisher's exact test P = 0.724). Data from biochemical tests suggest the involvement of cytochrome P450 monooxygenases, esterases and glutatione S-transferases in the resistance of An. funestus population from Gbanikola (Wilcoxon test P <0.05). Evidence of biochemical resistance to insecticide was detected in An. funestus population from the district of Gbanikola, Bangui. This study suggests that detoxifying enzymes are involved in insecticide resistance of An. funestus. However, despite disruptive violence, further research is urgently needed to assess the insecticide susceptibility status of An. funestus population in all CAR regions; insecticide resistance could rapidly compromise the success of malaria control programs.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 16%
Student > Master 12 15%
Researcher 11 14%
Student > Bachelor 10 13%
Other 4 5%
Other 11 14%
Unknown 19 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 23%
Biochemistry, Genetics and Molecular Biology 10 13%
Environmental Science 9 11%
Medicine and Dentistry 7 9%
Social Sciences 5 6%
Other 13 16%
Unknown 18 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2016.
All research outputs
#4,447,737
of 8,714,371 outputs
Outputs from Parasites & Vectors
#1,212
of 2,487 outputs
Outputs of similar age
#137,458
of 273,117 outputs
Outputs of similar age from Parasites & Vectors
#87
of 186 outputs
Altmetric has tracked 8,714,371 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,487 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,117 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.